| http://purl.uniprot.org/citations/19028869 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19028869 | http://www.w3.org/2000/01/rdf-schema#comment | "The Saccharomyces cerevisiae Mec1-Ddc2 checkpoint kinase complex (the ortholog to human ATR-ATRIP) is an essential regulator of genomic integrity. The S. cerevisiae BRCT repeat protein Dpb11 functions in the initiation of both DNA replication and cell cycle checkpoints. Here, we report a genetic and physical interaction between Dpb11 and Mec1-Ddc2. A C-terminal domain of Dpb11 is sufficient to associate with Mec1-Ddc2 and strongly stimulates the kinase activity of Mec1 in a Ddc2-dependent manner. Furthermore, Mec1 phosphorylates Dpb11 and thereby amplifies the stimulating effect of Dpb11 on Mec1-Ddc2 kinase activity. Thus, Dpb11 is a functional ortholog of human TopBP1, and the Mec1/ATR activation mechanism is conserved from yeast to humans."xsd:string |
| http://purl.uniprot.org/citations/19028869 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0806621105"xsd:string |
| http://purl.uniprot.org/citations/19028869 | http://purl.uniprot.org/core/author | "Cortez D."xsd:string |
| http://purl.uniprot.org/citations/19028869 | http://purl.uniprot.org/core/author | "Nam E.A."xsd:string |
| http://purl.uniprot.org/citations/19028869 | http://purl.uniprot.org/core/author | "Mordes D.A."xsd:string |
| http://purl.uniprot.org/citations/19028869 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19028869 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19028869 | http://purl.uniprot.org/core/pages | "18730-18734"xsd:string |
| http://purl.uniprot.org/citations/19028869 | http://purl.uniprot.org/core/title | "Dpb11 activates the Mec1-Ddc2 complex."xsd:string |
| http://purl.uniprot.org/citations/19028869 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/19028869 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19028869 |
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