| http://purl.uniprot.org/citations/19029303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19029303 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19029303 | http://www.w3.org/2000/01/rdf-schema#comment | "The RNA-binding protein IGF2BP1 (IGF-II mRNA binding protein 1) stabilizes the c-myc RNA by associating with the Coding Region instability Determinant (CRD). If and how other proteins cooperate with IGF2BP1 in promoting stabilization of the c-myc mRNA via the CRD remained elusive. Here, we identify various RNA-binding proteins that associate with IGF2BP1 in an RNA-dependent fashion. Four of these proteins (HNRNPU, SYNCRIP, YBX1, and DHX9) were essential to ensure stabilization of the c-myc mRNA via the CRD. These factors associate with IGF2BP1 in a CRD-dependent manner, co-distribute with IGF2BP1 in non-polysomal fractions comprising c-myc mRNA, and colocalize with IGF2BP1 in the cytoplasm. A selective shift of relative c-myc mRNA levels to the polysomal fraction is observed upon IGF2BP1 knockdown. These findings suggest that IGF2BP1 in complex with at least four proteins promotes CRD-mediated mRNA stabilization. Complex formation at the CRD presumably limits the transfer of c-myc mRNA to the polysomal fraction and subsequent translation-coupled decay."xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.org/dc/terms/identifier | "doi:10.1261/rna.1175909"xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.org/dc/terms/identifier | "doi:10.1261/rna.1175909"xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.uniprot.org/core/author | "Buchmeier S."xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.uniprot.org/core/author | "Buchmeier S."xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.uniprot.org/core/author | "Schierhorn A."xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.uniprot.org/core/author | "Schierhorn A."xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.uniprot.org/core/author | "Wahle E."xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.uniprot.org/core/author | "Wahle E."xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.uniprot.org/core/author | "Koehn M."xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.uniprot.org/core/author | "Koehn M."xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.uniprot.org/core/author | "Baude A."xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.uniprot.org/core/author | "Baude A."xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.uniprot.org/core/author | "Lederer M."xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.uniprot.org/core/author | "Lederer M."xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.uniprot.org/core/author | "Huettelmaiery S."xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.uniprot.org/core/author | "Huettelmaiery S."xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.uniprot.org/core/author | "Stoehr N."xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.uniprot.org/core/author | "Stoehr N."xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.uniprot.org/core/author | "Weidensdorfer D."xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.uniprot.org/core/author | "Weidensdorfer D."xsd:string |
| http://purl.uniprot.org/citations/19029303 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19029303 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |