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http://purl.uniprot.org/citations/19033397http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19033397http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The present study was conducted to confirm possible associations between candidate genes from genome-wide association studies and type 2 diabetes in Japanese diabetic patients and a community-based general population. A total of 11 previously reported single-nucleotide polymorphisms (SNPs) from the TCF7L2, CDKAL1, HHEX, IGF2BP2, CDKN2A/B, SLC30A8, and KCNJ11 genes were analyzed.

Research design and methods

Candidate SNPs were genotyped in 506 type 2 diabetic patients and 402 control subjects and meta-analyzed with six previous association studies in Japanese patients. Associations with fasting plasma insulin levels were investigated in a general population sample (n = 1,963, 61 +/-13 years).

Results

In our case-control subjects, susceptibility to type 2 diabetes was replicated in TCF7L2 (rs12255372), CDKAL1 (rs7756992, rs7754840), HHEX (rs7923837), IGF2BP2 (rs4402960 and rs1470579), CDKN2A/B (rs10811661), and SLC30A8 (rs13266634). In addition to these polymorphisms, meta-analysis confirmed the association of type 2 diabetes susceptibility with KCNJ11 rs5219, TCF7L2 rs7903146, and HHEX rs1111875. The TCF7L2 rs12255372 polymorphism showed the highest odds ratio (OR) for type 2 diabetes (OR 1.714 [1.298-2.263]). Odds ratio of other polymorphisms ranged from 1.13 to 1.41. The risk allele of CDKAL1 rs7756992 was significantly associated with lower insulin levels in type 2 diabetic patients after adjustment for other confounding factors.

Conclusions

Type 2 diabetes susceptibility of seven candidate genes was confirmed in Japanese. Conservation of susceptible loci for type 2 diabetes was independent of ethnic background."xsd:string
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http://purl.uniprot.org/citations/19033397http://purl.uniprot.org/core/author"Makino H."xsd:string
http://purl.uniprot.org/citations/19033397http://purl.uniprot.org/core/author"Miki T."xsd:string
http://purl.uniprot.org/citations/19033397http://purl.uniprot.org/core/author"Osawa H."xsd:string
http://purl.uniprot.org/citations/19033397http://purl.uniprot.org/core/author"Kohara K."xsd:string
http://purl.uniprot.org/citations/19033397http://purl.uniprot.org/core/author"Tabara Y."xsd:string
http://purl.uniprot.org/citations/19033397http://purl.uniprot.org/core/author"Kawamoto R."xsd:string
http://purl.uniprot.org/citations/19033397http://purl.uniprot.org/core/author"Shimizu I."xsd:string
http://purl.uniprot.org/citations/19033397http://purl.uniprot.org/core/author"Onuma H."xsd:string
http://purl.uniprot.org/citations/19033397http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19033397http://purl.uniprot.org/core/name"Diabetes"xsd:string
http://purl.uniprot.org/citations/19033397http://purl.uniprot.org/core/pages"493-498"xsd:string
http://purl.uniprot.org/citations/19033397http://purl.uniprot.org/core/title"Replication study of candidate genes associated with type 2 diabetes based on genome-wide screening."xsd:string
http://purl.uniprot.org/citations/19033397http://purl.uniprot.org/core/volume"58"xsd:string
http://purl.uniprot.org/citations/19033397http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19033397
http://purl.uniprot.org/citations/19033397http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19033397
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