| http://purl.uniprot.org/citations/19033441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19033441 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19033441 | http://www.w3.org/2000/01/rdf-schema#comment | "NEMO (NF-kappaB essential modulator) is a regulatory protein essential to the canonical NF-kappaB signaling pathway, notably involved in immune and inflammatory responses, apoptosis, and oncogenesis. Here, we report that the zinc finger (ZF) motif, located in the regulatory C-terminal half of NEMO, forms a specific complex with ubiquitin. We have investigated the NEMO ZF-ubiquitin interaction and proposed a structural model of the complex based on NMR, fluorescence, and mutagenesis data and on the sequence homology with the polymerase eta ubiquitin-binding zinc finger involved in DNA repair. Functional complementation assays and in vivo pull-down experiments further show that ZF residues involved in ubiquitin binding are functionally important and required for NF-kappaB signaling in response to tumor necrosis factor-alpha. Thus, our findings indicate that NEMOZFisa bona fide ubiquitin-binding domain of the ubiquitin-binding zinc finger type."xsd:string |
| http://purl.uniprot.org/citations/19033441 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m806655200"xsd:string |
| http://purl.uniprot.org/citations/19033441 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m806655200"xsd:string |
| http://purl.uniprot.org/citations/19033441 | http://purl.uniprot.org/core/author | "Traincard F."xsd:string |
| http://purl.uniprot.org/citations/19033441 | http://purl.uniprot.org/core/author | "Traincard F."xsd:string |
| http://purl.uniprot.org/citations/19033441 | http://purl.uniprot.org/core/author | "Veron M."xsd:string |
| http://purl.uniprot.org/citations/19033441 | http://purl.uniprot.org/core/author | "Veron M."xsd:string |
| http://purl.uniprot.org/citations/19033441 | http://purl.uniprot.org/core/author | "Grubisha O."xsd:string |
| http://purl.uniprot.org/citations/19033441 | http://purl.uniprot.org/core/author | "Grubisha O."xsd:string |
| http://purl.uniprot.org/citations/19033441 | http://purl.uniprot.org/core/author | "Cordier F."xsd:string |
| http://purl.uniprot.org/citations/19033441 | http://purl.uniprot.org/core/author | "Cordier F."xsd:string |
| http://purl.uniprot.org/citations/19033441 | http://purl.uniprot.org/core/author | "Agou F."xsd:string |
| http://purl.uniprot.org/citations/19033441 | http://purl.uniprot.org/core/author | "Agou F."xsd:string |
| http://purl.uniprot.org/citations/19033441 | http://purl.uniprot.org/core/author | "Delepierre M."xsd:string |
| http://purl.uniprot.org/citations/19033441 | http://purl.uniprot.org/core/author | "Delepierre M."xsd:string |
| http://purl.uniprot.org/citations/19033441 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19033441 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19033441 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/19033441 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/19033441 | http://purl.uniprot.org/core/pages | "2902-2907"xsd:string |
| http://purl.uniprot.org/citations/19033441 | http://purl.uniprot.org/core/pages | "2902-2907"xsd:string |
| http://purl.uniprot.org/citations/19033441 | http://purl.uniprot.org/core/title | "The zinc finger of NEMO is a functional ubiquitin-binding domain."xsd:string |
| http://purl.uniprot.org/citations/19033441 | http://purl.uniprot.org/core/title | "The zinc finger of NEMO is a functional ubiquitin-binding domain."xsd:string |