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http://purl.uniprot.org/citations/19035513http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19035513http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The immunologic events that lead to persistent joint inflammation in certain patients with Lyme arthritis post-antibiotic treatment have been elusive so far. The prevalence of this condition is highest in individuals with rheumatoid arthritis-associated HLA-DR alleles. This study was undertaken to generate a murine model with persistent arthritis post-antibiotic treatment.

Methods

We have previously shown that CD28(-/-) mice develop intermittent monarticular Lyme arthritis that is responsive to antibiotics. Since there seems to be a link in humans between persistent arthritic manifestations post-antibiotic treatment and the HLA-DR4 allele, we generated DR4+/+CD28(-/-)MHCII(-/-) mice, infected them with Borrelia burgdorferi, and subsequently treated them with antibiotics.

Results

Thirty-eight percent of the B burgdorferi-infected DR4+/+CD28(-/-)MHCII(-/-) mice, but none of the B burgdorferi-infected CD28(-/-)MHCII(-/-) mice, remained arthritic post-antibiotic treatment. A significant fraction (36%) of these mice, but none of the mice in which arthritis resolved, had serum antibodies to outer surface protein A of B burgdorferi. After abrogation of active B burgdorferi infection, the inflammatory reaction in mice with persistent joint inflammation was restricted to the joints, since their draining lymph nodes were no longer enlarged. Increased CD20 and interferon-gamma messenger RNA expression in the inflamed joints of these mice suggested a possible role of B cells and inflammatory cytokines in the pathogenesis of persistent arthritis post-antibiotic treatment.

Conclusion

The establishment of this murine model allows, for the first time, the elucidation of the immunologic events that lead to persistent Lyme arthritis post-antibiotic therapy in genetically susceptible individuals."xsd:string
http://purl.uniprot.org/citations/19035513http://purl.org/dc/terms/identifier"doi:10.1002/art.24028"xsd:string
http://purl.uniprot.org/citations/19035513http://purl.uniprot.org/core/author"Huber B.T."xsd:string
http://purl.uniprot.org/citations/19035513http://purl.uniprot.org/core/author"Iliopoulou B.P."xsd:string
http://purl.uniprot.org/citations/19035513http://purl.uniprot.org/core/author"Alroy J."xsd:string
http://purl.uniprot.org/citations/19035513http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/19035513http://purl.uniprot.org/core/name"Arthritis Rheum"xsd:string
http://purl.uniprot.org/citations/19035513http://purl.uniprot.org/core/pages"3892-3901"xsd:string
http://purl.uniprot.org/citations/19035513http://purl.uniprot.org/core/title"Persistent arthritis in Borrelia burgdorferi-infected HLA-DR4-positive CD28-negative mice post-antibiotic treatment."xsd:string
http://purl.uniprot.org/citations/19035513http://purl.uniprot.org/core/volume"58"xsd:string
http://purl.uniprot.org/citations/19035513http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19035513
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