| http://purl.uniprot.org/citations/19037087 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19037087 | http://www.w3.org/2000/01/rdf-schema#comment | "Rottlerin has been shown to induce antiproliferation and apoptosis of human cancer cell lines. In this study, we demonstrate a novel mechanism of rottlerin-induced apoptosis via death receptor (DR) 5 upregulation. We found that treatment with rottlerin significantly induces DR5 expression both at its messenger RNA and protein levels. Downregulation of DR5 expression with small-interfering RNA (siRNA) efficiently attenuated rottlerin-induced apoptosis, showing that the critical role of DR5 in this cell death. Rottlerin-induced DR5 upregulation was accompanied by CCAAT/enhancer-binding protein-homologous protein (CHOP) protein expression and rottlerin-induced increase of DR5 promoter activity was diminished by mutation of a CHOP-binding site of DR5 promoter. Although rottlerin is known to be as an inhibitor of novel isoforms of protein kinase C (PKC), specifically PKC delta, not only suppression of PKC delta expression by siRNA but also overexpression of wild-type-PKC delta or dominant-negative-PKC delta did not affect the rottlerin-mediated induction of DR5 in our study. These results suggest that rottlerin induces upregulation of DR5 via PKC delta-independent pathway. Furthermore, subtoxic dose of rottlerin sensitizes human cancer cells, but not normal cells, to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis. Thus, DR5-mediated apoptosis, which is induced by rottlerin alone or by the combined treatment with rottlerin and TRAIL, may offer a new therapeutic strategy against cancer."xsd:string |
| http://purl.uniprot.org/citations/19037087 | http://purl.org/dc/terms/identifier | "doi:10.1093/carcin/bgn265"xsd:string |
| http://purl.uniprot.org/citations/19037087 | http://purl.uniprot.org/core/author | "Park J.W."xsd:string |
| http://purl.uniprot.org/citations/19037087 | http://purl.uniprot.org/core/author | "Lim J.H."xsd:string |
| http://purl.uniprot.org/citations/19037087 | http://purl.uniprot.org/core/author | "Choi K.S."xsd:string |
| http://purl.uniprot.org/citations/19037087 | http://purl.uniprot.org/core/author | "Park Y.B."xsd:string |
| http://purl.uniprot.org/citations/19037087 | http://purl.uniprot.org/core/author | "Kwon T.K."xsd:string |
| http://purl.uniprot.org/citations/19037087 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19037087 | http://purl.uniprot.org/core/name | "Carcinogenesis"xsd:string |
| http://purl.uniprot.org/citations/19037087 | http://purl.uniprot.org/core/pages | "729-736"xsd:string |
| http://purl.uniprot.org/citations/19037087 | http://purl.uniprot.org/core/title | "Rottlerin induces apoptosis via death receptor 5 (DR5) upregulation through CHOP-dependent and PKC delta-independent mechanism in human malignant tumor cells."xsd:string |
| http://purl.uniprot.org/citations/19037087 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/19037087 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19037087 |
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