| http://purl.uniprot.org/citations/19038866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19038866 | http://www.w3.org/2000/01/rdf-schema#comment | "The role of apurinic/apyrimidinic endonuclease-1/redox factor-1 (Ref-1) in vascular smooth muscle cells has yet to be clearly elucidated. Therefore, we attempted to determine the roles of Ref-1 in the migration induced by platelet-derived growth factor (PDGF)-BB and in its signaling in rat aortic smooth muscle cells (RASMCs). Cellular migration, superoxide (O(2)(-*)) production, Rac-1 activity, and neointima formation were determined in cells transfected with adenoviruses encoding for Ref-1 (AdRef-1) and small interference RNA of Ref-1. Overexpression of Ref-1 induced by treatment with RASMCs coupled with AdRef-1 inhibited the migration induced by PDGF-BB. PDGF-BB also increased the phosphorylation of the PDGFbeta receptor, spleen tyrosine kinase (Syk), mitogen-activated protein kinase, and heat shock protein 27, but these increases were significantly inhibited by AdRef-1 treatment. PDGF-BB increased O(2)(-*) production and Rac-1 activity, and these were diminished in cells transfected with AdRef-1. In contrast, RASMC migration, phosphorylation of Syk and O(2)(-*) production in response to PDGF-BB were increased by the knock down of Ref-1 with small interference RNA. The phosphorylation of PDGFbeta receptor in response to PDGF-BB was inhibited completely by the Syk inhibitor and was partly attenuated by a NADPH oxidase inhibitor. PDGF-BB increased the sprout outgrowth of the aortic ring ex vivo, which was inhibited in the AdRef-1-infected RASMCs as compared with the controls. Balloon injury-induced neointimal formation was significantly attenuated by the gene transfer of AdRef-1. These results indicate that Ref-1 inhibits the PDGF-mediated migration signal via the inhibition of reactive oxygen species-mediated Syk activity in RASMCs."xsd:string |
| http://purl.uniprot.org/citations/19038866 | http://purl.org/dc/terms/identifier | "doi:10.1161/circresaha.108.178699"xsd:string |
| http://purl.uniprot.org/citations/19038866 | http://purl.uniprot.org/core/author | "Kim H.S."xsd:string |
| http://purl.uniprot.org/citations/19038866 | http://purl.uniprot.org/core/author | "Lee H.M."xsd:string |
| http://purl.uniprot.org/citations/19038866 | http://purl.uniprot.org/core/author | "Park S.H."xsd:string |
| http://purl.uniprot.org/citations/19038866 | http://purl.uniprot.org/core/author | "Kim B."xsd:string |
| http://purl.uniprot.org/citations/19038866 | http://purl.uniprot.org/core/author | "Lee C.K."xsd:string |
| http://purl.uniprot.org/citations/19038866 | http://purl.uniprot.org/core/author | "Lee S.K."xsd:string |
| http://purl.uniprot.org/citations/19038866 | http://purl.uniprot.org/core/author | "Bae Y.M."xsd:string |
| http://purl.uniprot.org/citations/19038866 | http://purl.uniprot.org/core/author | "Irani K."xsd:string |
| http://purl.uniprot.org/citations/19038866 | http://purl.uniprot.org/core/author | "Choi W.S."xsd:string |
| http://purl.uniprot.org/citations/19038866 | http://purl.uniprot.org/core/author | "Jeon B.H."xsd:string |
| http://purl.uniprot.org/citations/19038866 | http://purl.uniprot.org/core/author | "Won K.J."xsd:string |
| http://purl.uniprot.org/citations/19038866 | http://purl.uniprot.org/core/author | "Park T.K."xsd:string |
| http://purl.uniprot.org/citations/19038866 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19038866 | http://purl.uniprot.org/core/name | "Circ Res"xsd:string |
| http://purl.uniprot.org/citations/19038866 | http://purl.uniprot.org/core/pages | "219-227"xsd:string |
| http://purl.uniprot.org/citations/19038866 | http://purl.uniprot.org/core/title | "Gene transfer of redox factor-1 inhibits neointimal formation: involvement of platelet-derived growth factor-beta receptor signaling via the inhibition of the reactive oxygen species-mediated Syk pathway."xsd:string |
| http://purl.uniprot.org/citations/19038866 | http://purl.uniprot.org/core/volume | "104"xsd:string |
| http://purl.uniprot.org/citations/19038866 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19038866 |
| http://purl.uniprot.org/citations/19038866 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19038866 |
| http://purl.uniprot.org/uniprot/P43138#attribution-0FA44EA723F2DBA88FFAB58591B1BC9C | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19038866 |
| http://purl.uniprot.org/uniprot/#_A0A0C4DGK8-mappedCitation-19038866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19038866 |
| http://purl.uniprot.org/uniprot/#_A6J6S2-mappedCitation-19038866 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19038866 |