| http://purl.uniprot.org/citations/19039140 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19039140 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19039140 | http://www.w3.org/2000/01/rdf-schema#comment | "Hepatic glucose production is critical for basal brain function and survival when dietary glucose is unavailable. Glucose-6-phosphatase (G6Pase) is an essential, rate-limiting enzyme that serves as a terminal gatekeeper for hepatic glucose release into the plasma. Mutations in G6Pase result in Von Gierke's disease (glycogen storage disease-1a), a potentially fatal genetic disorder. We have identified the transcriptional coactivator SRC-2 as a regulator of fasting hepatic glucose release, a function that SRC-2 performs by controlling the expression of hepatic G6Pase. SRC-2 modulates G6Pase expression directly by acting as a coactivator with the orphan nuclear receptor RORalpha. In addition, SRC-2 ablation, in both a whole-body and liver-specific manner, resulted in a Von Gierke's disease phenotype in mice. Our results position SRC-2 as a critical regulator of mammalian glucose production."xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1164847"xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1164847"xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.uniprot.org/core/author | "An J."xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.uniprot.org/core/author | "An J."xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.uniprot.org/core/author | "Moore D."xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.uniprot.org/core/author | "Moore D."xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.uniprot.org/core/author | "Chan L."xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.uniprot.org/core/author | "Chan L."xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.uniprot.org/core/author | "Newgard C.B."xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.uniprot.org/core/author | "Newgard C.B."xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.uniprot.org/core/author | "Saha P."xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.uniprot.org/core/author | "Saha P."xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.uniprot.org/core/author | "O'Malley B.W."xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.uniprot.org/core/author | "O'Malley B.W."xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.uniprot.org/core/author | "Demayo F."xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.uniprot.org/core/author | "Demayo F."xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.uniprot.org/core/author | "York B."xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.uniprot.org/core/author | "York B."xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.uniprot.org/core/author | "Finegold M."xsd:string |
| http://purl.uniprot.org/citations/19039140 | http://purl.uniprot.org/core/author | "Finegold M."xsd:string |