| http://purl.uniprot.org/citations/19041897 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19041897 | http://www.w3.org/2000/01/rdf-schema#comment | "Wfs1-deficient mice were generated by disrupting the 8th exon of Wfs1 gene. Reproduction rates of homozygous Wfs1-deficient mice were slightly below the expected values, they displayed intolerance to glucose and overall lower body weight. The present behavioural study was performed in female Wfs1-deficient mice due to their milder metabolic disturbances. Non-fasting blood glucose levels did not differ between homozygous Wfs1-deficient mice and wild-type littermates. While there was no difference in baseline plasma corticosterone, exposure to stress induced a nearly three-fold elevation of corticosterone in Wfs1-deficient mice in relation to wild-type littermates. Wfs1-deficient mice did not display obvious shortcomings in sensory and motor functioning as exemplified by intact responses in conditioned learning paradigms and rota-rod test. Locomotor activity of Wfs1-deficient mice was significantly lower only in brightly lit environment. Short-term isolation had a significant anxiogenic-like effect on the behaviour of Wfs1-deficient mice in dark/light exploration test. Lower exploratory activity of Wfs1-deficient mice in the plus-maze was antagonised by pre-treatment with diazepam (1 mg/kg), a GABA(A) receptor agonist. Wfs1-deficient mice displayed increased anxiety-like behaviour in hyponeophagia test. The locomotor stimulatory effects of amphetamine (2.5-7.5 mg/kg) and apomorphine (3 mg/kg) were significantly attenuated and facilitated, respectively, in Wfs1-deficient mice. There were no differences between Wfs1-deficient mice and wild-types in forced swimming behaviour and conditioned fear responses. Subtle impairments in reversal learning were apparent in Wfs1-deficient mice in the Morris water maze. Altogether, the present study demonstrates impaired behavioural adaptation of Wfs1-deficient mice in stress-inducing situations. It is likely that Wfs1 protein plays a major role in the behavioural adaptation mechanisms to novel and stressful environments."xsd:string |
| http://purl.uniprot.org/citations/19041897 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbr.2008.11.007"xsd:string |
| http://purl.uniprot.org/citations/19041897 | http://purl.uniprot.org/core/author | "Koks S."xsd:string |
| http://purl.uniprot.org/citations/19041897 | http://purl.uniprot.org/core/author | "Abramov U."xsd:string |
| http://purl.uniprot.org/citations/19041897 | http://purl.uniprot.org/core/author | "Innos J."xsd:string |
| http://purl.uniprot.org/citations/19041897 | http://purl.uniprot.org/core/author | "Kurrikoff K."xsd:string |
| http://purl.uniprot.org/citations/19041897 | http://purl.uniprot.org/core/author | "Luuk H."xsd:string |
| http://purl.uniprot.org/citations/19041897 | http://purl.uniprot.org/core/author | "Plaas M."xsd:string |
| http://purl.uniprot.org/citations/19041897 | http://purl.uniprot.org/core/author | "Raud S."xsd:string |
| http://purl.uniprot.org/citations/19041897 | http://purl.uniprot.org/core/author | "Vasar E."xsd:string |
| http://purl.uniprot.org/citations/19041897 | http://purl.uniprot.org/core/author | "Sutt S."xsd:string |
| http://purl.uniprot.org/citations/19041897 | http://purl.uniprot.org/core/author | "Lasner H."xsd:string |
| http://purl.uniprot.org/citations/19041897 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19041897 | http://purl.uniprot.org/core/name | "Behav Brain Res"xsd:string |
| http://purl.uniprot.org/citations/19041897 | http://purl.uniprot.org/core/pages | "334-345"xsd:string |
| http://purl.uniprot.org/citations/19041897 | http://purl.uniprot.org/core/title | "Wfs1-deficient mice display impaired behavioural adaptation in stressful environment."xsd:string |
| http://purl.uniprot.org/citations/19041897 | http://purl.uniprot.org/core/volume | "198"xsd:string |
| http://purl.uniprot.org/citations/19041897 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19041897 |
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