| http://purl.uniprot.org/citations/19046568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19046568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19046568 | http://www.w3.org/2000/01/rdf-schema#comment | "Glucagon receptor (Gcgr) signaling maintains hepatic glucose production during the fasting state; however, the importance of the Gcgr for lipid metabolism is unclear. We show here that fasted Gcgr-/-mice exhibit a significant increase in hepatic triglyceride secretion and fasting increases fatty acid oxidation (FAO) in wild-type (WT) but not in Gcgr-/-mice. Moreover fasting upregulated the expression of FAO-related hepatic mRNA transcripts in Gcgr+/+ but not in Gcgr-/-mice. Exogenous glucagon administration reduced plasma triglycerides in WT mice, inhibited TG synthesis and secretion, and stimulated FA beta oxidation in Gcgr+/+ hepatocytes. The actions of glucagon on TG synthesis and FAO were abolished in PPARalpha-/-hepatocytes. These findings demonstrate that the Gcgr receptor is required for control of lipid metabolism during the adaptive metabolic response to fasting."xsd:string |
| http://purl.uniprot.org/citations/19046568 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2008.09.008"xsd:string |
| http://purl.uniprot.org/citations/19046568 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cmet.2008.09.008"xsd:string |
| http://purl.uniprot.org/citations/19046568 | http://purl.uniprot.org/core/author | "Maziarz M."xsd:string |
| http://purl.uniprot.org/citations/19046568 | http://purl.uniprot.org/core/author | "Maziarz M."xsd:string |
| http://purl.uniprot.org/citations/19046568 | http://purl.uniprot.org/core/author | "Charron M.J."xsd:string |
| http://purl.uniprot.org/citations/19046568 | http://purl.uniprot.org/core/author | "Charron M.J."xsd:string |
| http://purl.uniprot.org/citations/19046568 | http://purl.uniprot.org/core/author | "Drucker D.J."xsd:string |
| http://purl.uniprot.org/citations/19046568 | http://purl.uniprot.org/core/author | "Drucker D.J."xsd:string |
| http://purl.uniprot.org/citations/19046568 | http://purl.uniprot.org/core/author | "Maida A."xsd:string |
| http://purl.uniprot.org/citations/19046568 | http://purl.uniprot.org/core/author | "Maida A."xsd:string |
| http://purl.uniprot.org/citations/19046568 | http://purl.uniprot.org/core/author | "Baggio L.L."xsd:string |
| http://purl.uniprot.org/citations/19046568 | http://purl.uniprot.org/core/author | "Baggio L.L."xsd:string |
| http://purl.uniprot.org/citations/19046568 | http://purl.uniprot.org/core/author | "Longuet C."xsd:string |
| http://purl.uniprot.org/citations/19046568 | http://purl.uniprot.org/core/author | "Longuet C."xsd:string |
| http://purl.uniprot.org/citations/19046568 | http://purl.uniprot.org/core/author | "Sinclair E.M."xsd:string |
| http://purl.uniprot.org/citations/19046568 | http://purl.uniprot.org/core/author | "Sinclair E.M."xsd:string |
| http://purl.uniprot.org/citations/19046568 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19046568 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19046568 | http://purl.uniprot.org/core/name | "Cell Metab."xsd:string |
| http://purl.uniprot.org/citations/19046568 | http://purl.uniprot.org/core/name | "Cell Metab."xsd:string |
| http://purl.uniprot.org/citations/19046568 | http://purl.uniprot.org/core/pages | "359-371"xsd:string |
| http://purl.uniprot.org/citations/19046568 | http://purl.uniprot.org/core/pages | "359-371"xsd:string |