| http://purl.uniprot.org/citations/19047049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19047049 | http://www.w3.org/2000/01/rdf-schema#comment | "In this study we have investigated hyaluronan (HA)-mediated CD44 (an HA receptor) interactions with p300 (a histone acetyltransferase) and SIRT1 (a histone deacetylase) in human breast tumor cells (MCF-7 cells). Specifically, our results indicate that HA binding to CD44 up-regulates p300 expression and its acetyltransferase activity that, in turn, promotes acetylation of beta-catenin and NFkappaB-p65 leading to activation of beta-catenin-associated T-cell factor/lymphocyte enhancer factor transcriptional co-activation and NFkappaB-specific transcriptional up-regulation, respectively. These changes then cause the expression of the MDR1 (P-glycoprotein/P-gp) gene and the anti-apoptotic gene Bcl-x(L) resulting in chemoresistance in MCF-7 cells. Our data also show that down-regulation of p300, beta-catenin, or NFkappaB-p65 in MCF-7 cells (by transfecting cells with p300-, beta-catenin-, or NFkappaB-p65-specific small interfering RNA) inhibits the HA/CD44-mediated beta-catenin/NFkappaB-p65 acetylation and abrogates the aforementioned transcriptional activities. Subsequently, there is a significant decrease in both MDR1 and Bcl-x(L) gene expression and an enhancement in caspase-3 activity and chemosensitivity in the breast tumor cells. Further analyses indicate that activation of SIRT1 (deacetylase) by resveratrol (a natural antioxidant) induces SIRT1-p300 association and acetyltransferase inactivation, leading to deacetylation of HA/CD44-induced beta-catenin and NFkappaB-p65, inhibition of beta-catenin-T-cell factor/lymphocyte enhancer factor and NFkappaB-specific transcriptional activation, and the impairment of MDR1 and Bcl-x(L) gene expression. All these multiple effects lead to an activation of caspase-3 and a reduction of chemoresistance. Together, these findings suggest that the interactions between HA/CD44-stimulated p300 (acetyltransferase) and resveratrol-activated SIRT1 (deacetylase) play pivotal roles in regulating the balance between cell survival versus apoptosis, and multidrug resistance versus sensitivity in breast tumor cells."xsd:string |
| http://purl.uniprot.org/citations/19047049 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m806708200"xsd:string |
| http://purl.uniprot.org/citations/19047049 | http://purl.uniprot.org/core/author | "Xia W."xsd:string |
| http://purl.uniprot.org/citations/19047049 | http://purl.uniprot.org/core/author | "Wong G."xsd:string |
| http://purl.uniprot.org/citations/19047049 | http://purl.uniprot.org/core/author | "Bourguignon L.Y.W."xsd:string |
| http://purl.uniprot.org/citations/19047049 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19047049 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19047049 | http://purl.uniprot.org/core/pages | "2657-2671"xsd:string |
| http://purl.uniprot.org/citations/19047049 | http://purl.uniprot.org/core/title | "Hyaluronan-mediated CD44 interaction with p300 and SIRT1 regulates beta-catenin signaling and NFkappaB-specific transcription activity leading to MDR1 and Bcl-xL gene expression and chemoresistance in breast tumor cells."xsd:string |
| http://purl.uniprot.org/citations/19047049 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19047049 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19047049 |
| http://purl.uniprot.org/citations/19047049 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19047049 |
| http://purl.uniprot.org/uniprot/P16070#attribution-59798C62F96C936A4BC9AC1FD5F05D75 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19047049 |
| http://purl.uniprot.org/uniprot/Q96EB6#attribution-59798C62F96C936A4BC9AC1FD5F05D75 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19047049 |
| http://purl.uniprot.org/uniprot/#_Q09472-mappedCitation-19047049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19047049 |
| http://purl.uniprot.org/uniprot/#_Q96EB6-mappedCitation-19047049 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19047049 |
| http://purl.uniprot.org/uniprot/Q09472 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19047049 |
| http://purl.uniprot.org/uniprot/Q96EB6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19047049 |