| http://purl.uniprot.org/citations/19048023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19048023 | http://www.w3.org/2000/01/rdf-schema#comment | "Methionine adenosyltransferase II (MAT II) is a key enzyme in cellular metabolism and catalyzes the formation of S-adenosylmethionine (SAMe) from L-methionine and ATP. Normal resting T lymphocytes have minimal MAT II activity, whereas activated proliferating T lymphocytes and transformed T leukemic cells show significantly enhanced MAT II activity. This work was carried out to examine the role of MAT II activity and SAMe biosynthesis in the survival of leukemic T cells. Inhibition of MAT II and the resultant decrease in SAMe levels enhanced expression of FasL mRNA and protein, and induced DISC (Death Inducing Signaling Complex) formation with FADD (Fas-associated Death Domain) and procaspase-8 recruitment, as well as concomitant increase in caspase-8 activation and decrease in c-FLIP(s) levels. Fas-initiated signaling induced by MAT II inhibition was observed to link to the mitochondrial pathway via Bid cleavage and to ultimately lead to increased caspase-3 activation and DNA fragmentation in these cells. Furthermore, blocking MAT 2A mRNA expression, which encodes the catalytic subunits of MAT II, using a small-interfering RNA approach enhanced FasL expression and cell death, validating the essential nature of MAT II activity in the survival of T leukemic cells."xsd:string |
| http://purl.uniprot.org/citations/19048023 | http://purl.org/dc/terms/identifier | "doi:10.1038/cr.2008.314"xsd:string |
| http://purl.uniprot.org/citations/19048023 | http://purl.uniprot.org/core/author | "Chen T."xsd:string |
| http://purl.uniprot.org/citations/19048023 | http://purl.uniprot.org/core/author | "Barve S."xsd:string |
| http://purl.uniprot.org/citations/19048023 | http://purl.uniprot.org/core/author | "McClain C.J."xsd:string |
| http://purl.uniprot.org/citations/19048023 | http://purl.uniprot.org/core/author | "Suttles J."xsd:string |
| http://purl.uniprot.org/citations/19048023 | http://purl.uniprot.org/core/author | "Joshi-Barve S."xsd:string |
| http://purl.uniprot.org/citations/19048023 | http://purl.uniprot.org/core/author | "Gobejishvili L."xsd:string |
| http://purl.uniprot.org/citations/19048023 | http://purl.uniprot.org/core/author | "Kharebava G."xsd:string |
| http://purl.uniprot.org/citations/19048023 | http://purl.uniprot.org/core/author | "Barve A.S."xsd:string |
| http://purl.uniprot.org/citations/19048023 | http://purl.uniprot.org/core/author | "Hote P.T."xsd:string |
| http://purl.uniprot.org/citations/19048023 | http://purl.uniprot.org/core/author | "Jani T.S."xsd:string |
| http://purl.uniprot.org/citations/19048023 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19048023 | http://purl.uniprot.org/core/name | "Cell Res"xsd:string |
| http://purl.uniprot.org/citations/19048023 | http://purl.uniprot.org/core/pages | "358-369"xsd:string |
| http://purl.uniprot.org/citations/19048023 | http://purl.uniprot.org/core/title | "Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells."xsd:string |
| http://purl.uniprot.org/citations/19048023 | http://purl.uniprot.org/core/volume | "19"xsd:string |
| http://purl.uniprot.org/citations/19048023 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19048023 |
| http://purl.uniprot.org/citations/19048023 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19048023 |
| http://purl.uniprot.org/uniprot/#_A0A140VJP5-mappedCitation-19048023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19048023 |
| http://purl.uniprot.org/uniprot/#_B4DFQ8-mappedCitation-19048023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19048023 |
| http://purl.uniprot.org/uniprot/#_B4DN74-mappedCitation-19048023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19048023 |
| http://purl.uniprot.org/uniprot/#_B4E1K2-mappedCitation-19048023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19048023 |
| http://purl.uniprot.org/uniprot/#_B4DEX8-mappedCitation-19048023 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19048023 |