| http://purl.uniprot.org/citations/19050234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19050234 | http://www.w3.org/2000/01/rdf-schema#comment | "Endogenous danger signals released from necrotic cells are thought to be sensed by phagocytes leading to secretion of IL-1alpha and neutrophilic recruitment. However, the mechanisms for IL-1alpha production and IL-1alpha-mediated sterile inflammation remain poorly understood. We report here that necrotic cell extracts elicited little secretion of CXCL1 and IL-6 from macrophages but robust production in mesothelial cells. The induction of CXCL1 as well as activation of NF-kappaB and MAPKs by cytosolic extracts required the presence of IL-1alpha in the necrotic cell. Conversely, expression of IL-1R and MyD88 but not IL-1alpha, RICK, TLR2, TLR4, TRIF, or inflammasome components in mesothelial cells was critical for the production of CXCL1. Furthermore, IL-1alpha was critical to induce the recruitment of neutrophils in the peritoneal cavity via CXCR2. These studies show that IL-1alpha is a key danger signal released from necrotic cells to trigger CXCL1 secretion and recruitment of neutrophils via IL-1R/MyD88 on neighboring mesothelial cells."xsd:string |
| http://purl.uniprot.org/citations/19050234 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.181.12.8194"xsd:string |
| http://purl.uniprot.org/citations/19050234 | http://purl.uniprot.org/core/author | "Park J.H."xsd:string |
| http://purl.uniprot.org/citations/19050234 | http://purl.uniprot.org/core/author | "Nunez G."xsd:string |
| http://purl.uniprot.org/citations/19050234 | http://purl.uniprot.org/core/author | "Harder J."xsd:string |
| http://purl.uniprot.org/citations/19050234 | http://purl.uniprot.org/core/author | "Iwakura Y."xsd:string |
| http://purl.uniprot.org/citations/19050234 | http://purl.uniprot.org/core/author | "Eigenbrod T."xsd:string |
| http://purl.uniprot.org/citations/19050234 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19050234 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/19050234 | http://purl.uniprot.org/core/pages | "8194-8198"xsd:string |
| http://purl.uniprot.org/citations/19050234 | http://purl.uniprot.org/core/title | "Cutting edge: critical role for mesothelial cells in necrosis-induced inflammation through the recognition of IL-1 alpha released from dying cells."xsd:string |
| http://purl.uniprot.org/citations/19050234 | http://purl.uniprot.org/core/volume | "181"xsd:string |
| http://purl.uniprot.org/citations/19050234 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19050234 |
| http://purl.uniprot.org/citations/19050234 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19050234 |
| http://purl.uniprot.org/uniprot/#_Q3U0Y6-mappedCitation-19050234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19050234 |
| http://purl.uniprot.org/uniprot/#_Q62161-mappedCitation-19050234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19050234 |
| http://purl.uniprot.org/uniprot/#_P35343-mappedCitation-19050234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19050234 |
| http://purl.uniprot.org/uniprot/#_P01582-mappedCitation-19050234 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19050234 |
| http://purl.uniprot.org/uniprot/Q62161 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19050234 |
| http://purl.uniprot.org/uniprot/P01582 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19050234 |
| http://purl.uniprot.org/uniprot/Q3U0Y6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19050234 |
| http://purl.uniprot.org/uniprot/P35343 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19050234 |