| http://purl.uniprot.org/citations/19052547 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19052547 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19052547 | http://www.w3.org/2000/01/rdf-schema#comment | "Many organisms can enter a dormant state or diapause to survive harsh environmental conditions for extended durations. When Caenorhabditis elegans larvae enter dauer they arrest feeding but remain active and motile, yet become stress-resistant, extremely long-lived and non-ageing. Entry into dauer is associated with a reduction in insulin-like signalling, the accumulation of nutritive resources and a concomitant global change in metabolism, yet the precise molecular and physiological processes that enable long-term survival in the absence of caloric intake remain largely unknown. We show here that C. elegans larvae that lack LKB1/AMPK (AMP-activated protein kinase) signalling enter dauer normally, but then rapidly consume their stored energy and prematurely expire following vital organ failure. We found that this signalling pathway acts in adipose-like tissues to downregulate triglyceride hydrolysis so that these lipid reserves are rationed to last the entire duration of the arrest. Indeed, the downregulation of adipose triglyceride lipase (ATGL-1) activity suppresses both the rapid depletion of stored lipids and reduced life span of AMPK mutant dauers, while AMPK directly phosphorylates ATGL-1. Finally, we show that the slow release of energy during dauer is critical for appropriate long-term osmoregulation, which fails as triglyceride resources become depleted. These mechanisms may be essential for survival through diapause, hibernation, or long-term fasting in diverse organisms and may also underlie AMPK-dependent life span extension."xsd:string |
| http://purl.uniprot.org/citations/19052547 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature07536"xsd:string |
| http://purl.uniprot.org/citations/19052547 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature07536"xsd:string |
| http://purl.uniprot.org/citations/19052547 | http://purl.uniprot.org/core/author | "Roy R."xsd:string |
| http://purl.uniprot.org/citations/19052547 | http://purl.uniprot.org/core/author | "Roy R."xsd:string |
| http://purl.uniprot.org/citations/19052547 | http://purl.uniprot.org/core/author | "Narbonne P."xsd:string |
| http://purl.uniprot.org/citations/19052547 | http://purl.uniprot.org/core/author | "Narbonne P."xsd:string |
| http://purl.uniprot.org/citations/19052547 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19052547 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19052547 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/19052547 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/19052547 | http://purl.uniprot.org/core/pages | "210-214"xsd:string |
| http://purl.uniprot.org/citations/19052547 | http://purl.uniprot.org/core/pages | "210-214"xsd:string |
| http://purl.uniprot.org/citations/19052547 | http://purl.uniprot.org/core/title | "Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival."xsd:string |
| http://purl.uniprot.org/citations/19052547 | http://purl.uniprot.org/core/title | "Caenorhabditis elegans dauers need LKB1/AMPK to ration lipid reserves and ensure long-term survival."xsd:string |
| http://purl.uniprot.org/citations/19052547 | http://purl.uniprot.org/core/volume | "457"xsd:string |
| http://purl.uniprot.org/citations/19052547 | http://purl.uniprot.org/core/volume | "457"xsd:string |
| http://purl.uniprot.org/citations/19052547 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19052547 |
| http://purl.uniprot.org/citations/19052547 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19052547 |
| http://purl.uniprot.org/citations/19052547 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19052547 |
| http://purl.uniprot.org/citations/19052547 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19052547 |
| http://purl.uniprot.org/uniprot/Q11186 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/19052547 |
| http://purl.uniprot.org/uniprot/Q11186#attribution-54A55052203A00ECF5E2971AD392FC4E | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19052547 |