| http://purl.uniprot.org/citations/19053830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19053830 | http://www.w3.org/2000/01/rdf-schema#comment | "Inhibitor of secreted frizzled related protein-1 (sFRP-1) would be a novel potential osteogenic agent, since loss of sFRP-1 affects osteoblast proliferation, differentiation, and activity, resulting in improved bone mineral density, quality, and strength. We have identified small molecule diarylsulfone sulfonamide derivatives as sFRP-1 inhibitors. Structure-activity relationship generated for various regions of the scaffold was utilized to improve the biochemical profile, resulting in the identification of potent selective analogues, such as 16 with desirable pharmaceutical profile."xsd:string |
| http://purl.uniprot.org/citations/19053830 | http://purl.org/dc/terms/identifier | "doi:10.1021/jm801069w"xsd:string |
| http://purl.uniprot.org/citations/19053830 | http://purl.uniprot.org/core/author | "Billiard J."xsd:string |
| http://purl.uniprot.org/citations/19053830 | http://purl.uniprot.org/core/author | "Shi M."xsd:string |
| http://purl.uniprot.org/citations/19053830 | http://purl.uniprot.org/core/author | "Stauffer B."xsd:string |
| http://purl.uniprot.org/citations/19053830 | http://purl.uniprot.org/core/author | "Krishnamurthy G."xsd:string |
| http://purl.uniprot.org/citations/19053830 | http://purl.uniprot.org/core/author | "Moran R."xsd:string |
| http://purl.uniprot.org/citations/19053830 | http://purl.uniprot.org/core/author | "Gopalsamy A."xsd:string |
| http://purl.uniprot.org/citations/19053830 | http://purl.uniprot.org/core/author | "Mangine A."xsd:string |
| http://purl.uniprot.org/citations/19053830 | http://purl.uniprot.org/core/author | "Ponce-de-Leon H."xsd:string |
| http://purl.uniprot.org/citations/19053830 | http://purl.uniprot.org/core/author | "Seestaller-Wehr L."xsd:string |
| http://purl.uniprot.org/citations/19053830 | http://purl.uniprot.org/core/author | "Fukayama S."xsd:string |
| http://purl.uniprot.org/citations/19053830 | http://purl.uniprot.org/core/author | "Bodine P."xsd:string |
| http://purl.uniprot.org/citations/19053830 | http://purl.uniprot.org/core/author | "Bahat R."xsd:string |
| http://purl.uniprot.org/citations/19053830 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19053830 | http://purl.uniprot.org/core/name | "J Med Chem"xsd:string |
| http://purl.uniprot.org/citations/19053830 | http://purl.uniprot.org/core/pages | "7670-7672"xsd:string |
| http://purl.uniprot.org/citations/19053830 | http://purl.uniprot.org/core/title | "Identification of diarylsulfone sulfonamides as secreted frizzled related protein-1 (sFRP-1) inhibitors."xsd:string |
| http://purl.uniprot.org/citations/19053830 | http://purl.uniprot.org/core/volume | "51"xsd:string |
| http://purl.uniprot.org/citations/19053830 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19053830 |
| http://purl.uniprot.org/citations/19053830 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19053830 |
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| http://purl.uniprot.org/uniprot/#_Q8N474-mappedCitation-19053830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19053830 |
| http://purl.uniprot.org/uniprot/#_Q05DS5-mappedCitation-19053830 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19053830 |