| http://purl.uniprot.org/citations/19056494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19056494 | http://www.w3.org/2000/01/rdf-schema#comment | "The lack of fragile X mental retardation protein (FMRP) causes fragile X syndrome, a common form of inherited mental retardation. Our previous studies revealed alterations in the differentiation of FMRP-deficient neural progenitors. Here, we show abnormalities in neurogenesis in the mouse and human embryonic FMRP-deficient brain as well as after in utero transfection of I304N mutated FMRP, which acts in a dominant negative manner in the wild-type mouse brain. Progenitors accumulated abnormally in the subventricular zone of the embryonic Fmr1-knockout (Fmr1-KO) mouse neocortex. An increased density of cells expressing sequentially an intermediate progenitor marker, T-box transcription factor (Tbr2), and a postmitotic neuron marker, T-brain 1 (Tbr1), indicated that the differentiation to glutamatergic cell lineages was particularly disturbed. These abnormalities were associated with an increased density of pyramidal cells of the layer V in the early postnatal neocortex suggesting a role for FMRP in the regulation of the differentiation of neocortical glutamatergic neurons."xsd:string |
| http://purl.uniprot.org/citations/19056494 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.nbd.2008.10.010"xsd:string |
| http://purl.uniprot.org/citations/19056494 | http://purl.uniprot.org/core/author | "Sun X."xsd:string |
| http://purl.uniprot.org/citations/19056494 | http://purl.uniprot.org/core/author | "Castren E."xsd:string |
| http://purl.uniprot.org/citations/19056494 | http://purl.uniprot.org/core/author | "Hokkanen M.E."xsd:string |
| http://purl.uniprot.org/citations/19056494 | http://purl.uniprot.org/core/author | "Castren M.L."xsd:string |
| http://purl.uniprot.org/citations/19056494 | http://purl.uniprot.org/core/author | "Kratochwil C.F."xsd:string |
| http://purl.uniprot.org/citations/19056494 | http://purl.uniprot.org/core/author | "Louhivuori V."xsd:string |
| http://purl.uniprot.org/citations/19056494 | http://purl.uniprot.org/core/author | "Tervonen T.A."xsd:string |
| http://purl.uniprot.org/citations/19056494 | http://purl.uniprot.org/core/author | "Zebryk P."xsd:string |
| http://purl.uniprot.org/citations/19056494 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19056494 | http://purl.uniprot.org/core/name | "Neurobiol Dis"xsd:string |
| http://purl.uniprot.org/citations/19056494 | http://purl.uniprot.org/core/pages | "250-259"xsd:string |
| http://purl.uniprot.org/citations/19056494 | http://purl.uniprot.org/core/title | "Aberrant differentiation of glutamatergic cells in neocortex of mouse model for fragile X syndrome."xsd:string |
| http://purl.uniprot.org/citations/19056494 | http://purl.uniprot.org/core/volume | "33"xsd:string |
| http://purl.uniprot.org/citations/19056494 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19056494 |
| http://purl.uniprot.org/citations/19056494 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19056494 |
| http://purl.uniprot.org/uniprot/#_A0A0K0MJ24-mappedCitation-19056494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19056494 |
| http://purl.uniprot.org/uniprot/#_E0CXX3-mappedCitation-19056494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19056494 |
| http://purl.uniprot.org/uniprot/#_E0CYI1-mappedCitation-19056494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19056494 |
| http://purl.uniprot.org/uniprot/#_E0CYN8-mappedCitation-19056494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19056494 |
| http://purl.uniprot.org/uniprot/#_D3YY51-mappedCitation-19056494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19056494 |
| http://purl.uniprot.org/uniprot/#_E0CZ37-mappedCitation-19056494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19056494 |
| http://purl.uniprot.org/uniprot/#_E0CZ54-mappedCitation-19056494 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19056494 |