| http://purl.uniprot.org/citations/1905813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1905813 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1905813 | http://www.w3.org/2000/01/rdf-schema#comment | "Signal-transduction pathways mediated by guanine nucleotide-binding regulatory proteins (G proteins) determine many of the responses of hematopoietic cells. A recently identified gene encoding a G protein alpha subunit, G alpha 16, is specifically expressed in human cells of the hematopoietic lineage. The G alpha 16 cDNA encodes a protein with predicted Mr of 43,500, which resembles the G q class of alpha subunits and does not include a pertussis toxin ADP-ribosylation site. In comparison with other G protein alpha subunits, the G alpha 16 predicted protein has distinctive amino acid sequences in the amino terminus, the region A guanine nucleotide-binding domain, and in the carboxyl-terminal third of the protein. Cell lines of myelomonocytic and T-cell phenotype express the G alpha 16 gene, but no expression is detectable in two B-cell lines or in nonhematopoietic cell lines. G alpha 16 gene expression is down-regulated in HL-60 cells induced to differentiate to neutrophils with dimethyl sulfoxide. Antisera generated from synthetic peptides that correspond to two regions of G alpha 16 specifically react with a protein of 42-to 43-kDa in bacterial strains that overexpress G alpha 16 and in HL-60 membranes. This protein is decreased in membranes from dimethyl sulfoxide-differentiated HL-60 cells and is not detectable in COS cell membranes. The restricted expression of this gene suggests that G alpha 16 regulates cell-type-specific signal-transduction pathways, which are not inhibited by pertussis toxin."xsd:string |
| http://purl.uniprot.org/citations/1905813 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.88.13.5587"xsd:string |
| http://purl.uniprot.org/citations/1905813 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.88.13.5587"xsd:string |
| http://purl.uniprot.org/citations/1905813 | http://purl.uniprot.org/core/author | "Simon M.I."xsd:string |
| http://purl.uniprot.org/citations/1905813 | http://purl.uniprot.org/core/author | "Simon M.I."xsd:string |
| http://purl.uniprot.org/citations/1905813 | http://purl.uniprot.org/core/author | "Slepak V.Z."xsd:string |
| http://purl.uniprot.org/citations/1905813 | http://purl.uniprot.org/core/author | "Slepak V.Z."xsd:string |
| http://purl.uniprot.org/citations/1905813 | http://purl.uniprot.org/core/author | "Amatruda T.T. III"xsd:string |
| http://purl.uniprot.org/citations/1905813 | http://purl.uniprot.org/core/author | "Amatruda T.T. III"xsd:string |
| http://purl.uniprot.org/citations/1905813 | http://purl.uniprot.org/core/author | "Steele D.A."xsd:string |
| http://purl.uniprot.org/citations/1905813 | http://purl.uniprot.org/core/author | "Steele D.A."xsd:string |
| http://purl.uniprot.org/citations/1905813 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1905813 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1905813 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/1905813 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/1905813 | http://purl.uniprot.org/core/pages | "5587-5591"xsd:string |
| http://purl.uniprot.org/citations/1905813 | http://purl.uniprot.org/core/pages | "5587-5591"xsd:string |
| http://purl.uniprot.org/citations/1905813 | http://purl.uniprot.org/core/title | "G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells."xsd:string |
| http://purl.uniprot.org/citations/1905813 | http://purl.uniprot.org/core/title | "G alpha 16, a G protein alpha subunit specifically expressed in hematopoietic cells."xsd:string |
| http://purl.uniprot.org/citations/1905813 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/1905813 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/1905813 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1905813 |
| http://purl.uniprot.org/citations/1905813 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1905813 |