| http://purl.uniprot.org/citations/19059246 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19059246 | http://www.w3.org/2000/01/rdf-schema#comment | "Fibroblast growth factor-21 (FGF21) signaling requires the presence of beta-Klotho, a co-receptor with a very short cytoplasmic domain. Here we show that FGF21 binds directly to beta-Klotho through its C-terminus. Serial C-terminal truncations of FGF21 weakened or even abrogated its interaction with beta-Klotho in a Biacore assay, and led to gradual loss of potency in a luciferase reporter assay but with little effect on maximal response. In contrast, serial N-terminal truncations of FGF21 had no impact on beta-Klotho binding. Interestingly, several of them exhibited characteristics of partial agonists with minimal effects on potency. These data demonstrate that the C-terminus of FGF21 is critical for binding to beta-Klotho and the N-terminus is critical for fibroblast growth factor receptor (FGFR) activation."xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.febslet.2008.11.023"xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/author | "Chen C."xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/author | "Cai L."xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/author | "Hawkins N."xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/author | "Wang M."xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/author | "Stevens J."xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/author | "Xu J."xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/author | "Smith S."xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/author | "Fisher S."xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/author | "Li Y.S."xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/author | "Belouski E."xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/author | "Patel J."xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/author | "Lindberg R."xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/author | "Veniant M."xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/author | "Michaels M.L."xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/author | "Hecht R."xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/author | "Yie J."xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/author | "Winters D."xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/author | "Steavenson S."xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/name | "FEBS Lett"xsd:string |
| http://purl.uniprot.org/citations/19059246 | http://purl.uniprot.org/core/pages | "19-24"xsd:string |