| http://purl.uniprot.org/citations/19059420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19059420 | http://www.w3.org/2000/01/rdf-schema#comment | "This paper evaluates the involvement of hippocampal ATP-sensitive potassium channels (K(ATP)) in learning and memory. After confirming expression of the Kir6.2 subunit in the CA3 region of C57BL/6J mice, we performed intra-hippocampal pharmacological injections of specific openers and blockers of K(ATP) channels. The opener diazoxide, the blocker tolbutamide, or a mixture of both, were bilaterally injected in the CA3 region before we subjected the animals to a fear conditioning paradigm. Diazoxide strongly impaired contextual memory of mice at both doses tested. This impairment was specifically reversed by co-injecting the blocker tolbutamide. Moreover, we studied the mnemonic abilities of mice deleted for the Kir6.2 subunit. These mice were backcrossed to C57BL/6J mice and tested in two learning paradigms. We found a significant impairment of contextual and tone memories in the Kir6.2 knock-out mice when compared with heterozygous or wild-type animals. Furthermore, these animals were also slightly impaired in a spatial version of the Morris water maze task. Our data suggest a specific involvement of hippocampal K(ATP) Kir6.2/SUR1 channels in memory processes."xsd:string |
| http://purl.uniprot.org/citations/19059420 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuropharm.2008.11.001"xsd:string |
| http://purl.uniprot.org/citations/19059420 | http://purl.uniprot.org/core/author | "French R.J."xsd:string |
| http://purl.uniprot.org/citations/19059420 | http://purl.uniprot.org/core/author | "Feng Z.P."xsd:string |
| http://purl.uniprot.org/citations/19059420 | http://purl.uniprot.org/core/author | "Bertholet A.M."xsd:string |
| http://purl.uniprot.org/citations/19059420 | http://purl.uniprot.org/core/author | "Betourne A."xsd:string |
| http://purl.uniprot.org/citations/19059420 | http://purl.uniprot.org/core/author | "Sun H.S."xsd:string |
| http://purl.uniprot.org/citations/19059420 | http://purl.uniprot.org/core/author | "Frances B."xsd:string |
| http://purl.uniprot.org/citations/19059420 | http://purl.uniprot.org/core/author | "Penicaud L."xsd:string |
| http://purl.uniprot.org/citations/19059420 | http://purl.uniprot.org/core/author | "Halley H."xsd:string |
| http://purl.uniprot.org/citations/19059420 | http://purl.uniprot.org/core/author | "Lassalle J.M."xsd:string |
| http://purl.uniprot.org/citations/19059420 | http://purl.uniprot.org/core/author | "Lorsignol A."xsd:string |
| http://purl.uniprot.org/citations/19059420 | http://purl.uniprot.org/core/author | "Labroue E."xsd:string |
| http://purl.uniprot.org/citations/19059420 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19059420 | http://purl.uniprot.org/core/name | "Neuropharmacology"xsd:string |
| http://purl.uniprot.org/citations/19059420 | http://purl.uniprot.org/core/pages | "615-625"xsd:string |
| http://purl.uniprot.org/citations/19059420 | http://purl.uniprot.org/core/title | "Involvement of hippocampal CA3 K(ATP) channels in contextual memory."xsd:string |
| http://purl.uniprot.org/citations/19059420 | http://purl.uniprot.org/core/volume | "56"xsd:string |
| http://purl.uniprot.org/citations/19059420 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19059420 |
| http://purl.uniprot.org/citations/19059420 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19059420 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GT90-mappedCitation-19059420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19059420 |
| http://purl.uniprot.org/uniprot/#_A0A1C7CYV4-mappedCitation-19059420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19059420 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GS56-mappedCitation-19059420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19059420 |
| http://purl.uniprot.org/uniprot/#_Q61743-mappedCitation-19059420 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19059420 |