Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/19060480http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19060480http://www.w3.org/2000/01/rdf-schema#comment"

Aim

The purpose of this study was to investigate the role of serotonergic genes in the development of alcohol dependence. The manifestation of alcohol withdrawal symptoms related to serotonergic polymorphisms in alcoholics was also examined.

Methods

The role of polymorphisms in the serotonin receptor 1A (5-HT1A), serotonin receptor 2A (5-HT2A), and the serotonin transporter gene (5-HTT) promotor region (5-HTTLPR) in the manifestation of individual alcohol withdrawal symptoms was investigated in 97 Korean male inpatients with alcohol dependence and 76 Korean healthy male subjects. The patient's alcohol withdrawal symptoms were assessed with the Clinical Institute Withdrawal Assessment for Alcohol (CIWA-Ar) scale.

Results

In the 5-HT1A receptor, the frequency of G-genotype (CC) was significantly higher in patients with alcohol dependence than in normal controls (chi(2) = 5.03, p = 0.025). The CIWA-Ar subscale scores of nausea, anxiety, and headache, and total CIWA-Ar scale scores were significantly higher in G+ genotypes (CG+ GG) than in G-genotype (p = 0.005, p = 0.004, p = 0.008, and p = 0.008, respectively).

Conclusion

The results suggest that the genetic polymorphism of the 5-HT1A receptor may play a role in alcohol dependence and polymorphisms of serotonergic genes may be important in withdrawal symptoms of patients with alcohol dependence."xsd:string
http://purl.uniprot.org/citations/19060480http://purl.org/dc/terms/identifier"doi:10.1159/000173008"xsd:string
http://purl.uniprot.org/citations/19060480http://purl.uniprot.org/core/author"Kim D.J."xsd:string
http://purl.uniprot.org/citations/19060480http://purl.uniprot.org/core/author"Lee Y.S."xsd:string
http://purl.uniprot.org/citations/19060480http://purl.uniprot.org/core/author"Choi S.W."xsd:string
http://purl.uniprot.org/citations/19060480http://purl.uniprot.org/core/author"Han D.H."xsd:string
http://purl.uniprot.org/citations/19060480http://purl.uniprot.org/core/author"Joe K.H."xsd:string
http://purl.uniprot.org/citations/19060480http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19060480http://purl.uniprot.org/core/name"Eur Addict Res"xsd:string
http://purl.uniprot.org/citations/19060480http://purl.uniprot.org/core/pages"39-46"xsd:string
http://purl.uniprot.org/citations/19060480http://purl.uniprot.org/core/title"Clinical manifestation of alcohol withdrawal symptoms related to genetic polymorphisms of two serotonin receptors and serotonin transporter."xsd:string
http://purl.uniprot.org/citations/19060480http://purl.uniprot.org/core/volume"15"xsd:string
http://purl.uniprot.org/citations/19060480http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19060480
http://purl.uniprot.org/citations/19060480http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19060480
http://purl.uniprot.org/uniprot/#_A0N5V3-mappedCitation-19060480http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19060480
http://purl.uniprot.org/uniprot/#_B2R7Y7-mappedCitation-19060480http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19060480
http://purl.uniprot.org/uniprot/#_B3VRS0-mappedCitation-19060480http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19060480
http://purl.uniprot.org/uniprot/#_B3VRS5-mappedCitation-19060480http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19060480
http://purl.uniprot.org/uniprot/#_B3VRB0-mappedCitation-19060480http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19060480
http://purl.uniprot.org/uniprot/#_B3VRB5-mappedCitation-19060480http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19060480
http://purl.uniprot.org/uniprot/#_B3VRC0-mappedCitation-19060480http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19060480
http://purl.uniprot.org/uniprot/#_B3VRQ0-mappedCitation-19060480http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19060480
http://purl.uniprot.org/uniprot/#_B3VRW0-mappedCitation-19060480http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19060480
http://purl.uniprot.org/uniprot/#_B3VRV0-mappedCitation-19060480http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19060480
▶