| http://purl.uniprot.org/citations/19060881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19060881 | http://www.w3.org/2000/01/rdf-schema#comment | "Aeroallergy results from maladaptive immune responses to ubiquitous, otherwise innocuous environmental proteins. Although the proteins targeted by aeroallergic responses represent a tiny fraction of the airborne proteins humans are exposed to, allergenicity is a quite public phenomenon-the same proteins typically behave as aeroallergens across the human population. Why particular proteins tend to act as allergens in susceptible hosts is a fundamental mechanistic question that remains largely unanswered. The main house-dust-mite allergen, Der p 2, has structural homology with MD-2 (also known as LY96), the lipopolysaccharide (LPS)-binding component of the Toll-like receptor (TLR) 4 signalling complex. Here we show that Der p 2 also has functional homology, facilitating signalling through direct interactions with the TLR4 complex, and reconstituting LPS-driven TLR4 signalling in the absence of MD-2. Mirroring this, airway sensitization and challenge with Der p 2 led to experimental allergic asthma in wild type and MD-2-deficient, but not TLR4-deficient, mice. Our results indicate that Der p 2 tends to be targeted by adaptive immune responses because of its auto-adjuvant properties. The fact that other members of the MD-2-like lipid-binding family are allergens, and that most defined major allergens are thought to be lipid-binding proteins, suggests that intrinsic adjuvant activity by such proteins and their accompanying lipid cargo may have some generality as a mechanism underlying the phenomenon of allergenicity."xsd:string |
| http://purl.uniprot.org/citations/19060881 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature07548"xsd:string |
| http://purl.uniprot.org/citations/19060881 | http://purl.uniprot.org/core/author | "Hegde R.S."xsd:string |
| http://purl.uniprot.org/citations/19060881 | http://purl.uniprot.org/core/author | "Karp C.L."xsd:string |
| http://purl.uniprot.org/citations/19060881 | http://purl.uniprot.org/core/author | "Blanchard C."xsd:string |
| http://purl.uniprot.org/citations/19060881 | http://purl.uniprot.org/core/author | "Madan R."xsd:string |
| http://purl.uniprot.org/citations/19060881 | http://purl.uniprot.org/core/author | "Visintin A."xsd:string |
| http://purl.uniprot.org/citations/19060881 | http://purl.uniprot.org/core/author | "Wills-Karp M."xsd:string |
| http://purl.uniprot.org/citations/19060881 | http://purl.uniprot.org/core/author | "Weiss J.P."xsd:string |
| http://purl.uniprot.org/citations/19060881 | http://purl.uniprot.org/core/author | "Trompette A."xsd:string |
| http://purl.uniprot.org/citations/19060881 | http://purl.uniprot.org/core/author | "Gioannini T.L."xsd:string |
| http://purl.uniprot.org/citations/19060881 | http://purl.uniprot.org/core/author | "Thorne P.S."xsd:string |
| http://purl.uniprot.org/citations/19060881 | http://purl.uniprot.org/core/author | "Divanovic S."xsd:string |
| http://purl.uniprot.org/citations/19060881 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19060881 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/19060881 | http://purl.uniprot.org/core/pages | "585-588"xsd:string |
| http://purl.uniprot.org/citations/19060881 | http://purl.uniprot.org/core/title | "Allergenicity resulting from functional mimicry of a Toll-like receptor complex protein."xsd:string |
| http://purl.uniprot.org/citations/19060881 | http://purl.uniprot.org/core/volume | "457"xsd:string |
| http://purl.uniprot.org/citations/19060881 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19060881 |
| http://purl.uniprot.org/citations/19060881 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19060881 |
| http://purl.uniprot.org/uniprot/#_A0A087WQZ9-mappedCitation-19060881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19060881 |
| http://purl.uniprot.org/uniprot/#_A2BHU8-mappedCitation-19060881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19060881 |
| http://purl.uniprot.org/uniprot/#_Q14AM4-mappedCitation-19060881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19060881 |
| http://purl.uniprot.org/uniprot/#_G3X8Y8-mappedCitation-19060881 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19060881 |