| http://purl.uniprot.org/citations/19060906 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19060906 | http://www.w3.org/2000/01/rdf-schema#comment | "Blood low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol and triglyceride levels are risk factors for cardiovascular disease. To dissect the polygenic basis of these traits, we conducted genome-wide association screens in 19,840 individuals and replication in up to 20,623 individuals. We identified 30 distinct loci associated with lipoprotein concentrations (each with P < 5 x 10(-8)), including 11 loci that reached genome-wide significance for the first time. The 11 newly defined loci include common variants associated with LDL cholesterol near ABCG8, MAFB, HNF1A and TIMD4; with HDL cholesterol near ANGPTL4, FADS1-FADS2-FADS3, HNF4A, LCAT, PLTP and TTC39B; and with triglycerides near AMAC1L2, FADS1-FADS2-FADS3 and PLTP. The proportion of individuals exceeding clinical cut points for high LDL cholesterol, low HDL cholesterol and high triglycerides varied according to an allelic dosage score (P < 10(-15) for each trend). These results suggest that the cumulative effect of multiple common variants contributes to polygenic dyslipidemia."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.org/dc/terms/identifier | "doi:10.1038/ng.291"xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Altshuler D."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Collins F.S."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Li Y."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Tanaka T."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Yang Q."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Scheet P."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Peltonen L."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Schlessinger D."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Collins R."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Kaplan L."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Boehnke M."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Burtt N.P."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Dupuis J."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Groop L."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Guiducci C."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Kathiresan S."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Laakso M."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Melander O."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Ordovas J.M."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Orho-Melander M."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Peloso G.M."xsd:string |
| http://purl.uniprot.org/citations/19060906 | http://purl.uniprot.org/core/author | "Tuomilehto J."xsd:string |