| http://purl.uniprot.org/citations/19061639 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19061639 | http://www.w3.org/2000/01/rdf-schema#comment | "Among the new players at the endoplasmic reticulum (ER)-mitochondria interface regulating interorganelle calcium signaling, those specifically involved during ER stress are not known at present. We report here that the truncated variant of the sarcoendoplasmic reticulum Ca(2+)-ATPase 1 (S1T) amplifies ER stress through the PERK-eIF2alpha-ATF4-CHOP pathway. S1T, which is localized in the ER-mitochondria microdomains, determines ER Ca(2+) depletion due to increased Ca(2+) leak, an increased number of ER-mitochondria contact sites, and inhibition of mitochondria movements. This leads to increased Ca(2+) transfer to mitochondria in both resting and stimulated conditions and activation of the mitochondrial apoptotic pathway. Interestingly, S1T knockdown was shown to prevent ER stress, mitochondrial Ca(2+) overload, and subsequent apoptosis. Thus, by bridging ER stress to apoptosis through increased ER-mitochondria Ca(2+) transfer, S1T acts as an essential determinant of cellular fate."xsd:string |
| http://purl.uniprot.org/citations/19061639 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2008.11.014"xsd:string |
| http://purl.uniprot.org/citations/19061639 | http://purl.uniprot.org/core/author | "Chami M."xsd:string |
| http://purl.uniprot.org/citations/19061639 | http://purl.uniprot.org/core/author | "Rizzuto R."xsd:string |
| http://purl.uniprot.org/citations/19061639 | http://purl.uniprot.org/core/author | "Oules B."xsd:string |
| http://purl.uniprot.org/citations/19061639 | http://purl.uniprot.org/core/author | "Paterlini-Brechot P."xsd:string |
| http://purl.uniprot.org/citations/19061639 | http://purl.uniprot.org/core/author | "Szabadkai G."xsd:string |
| http://purl.uniprot.org/citations/19061639 | http://purl.uniprot.org/core/author | "Tacine R."xsd:string |
| http://purl.uniprot.org/citations/19061639 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19061639 | http://purl.uniprot.org/core/name | "Mol Cell"xsd:string |
| http://purl.uniprot.org/citations/19061639 | http://purl.uniprot.org/core/pages | "641-651"xsd:string |
| http://purl.uniprot.org/citations/19061639 | http://purl.uniprot.org/core/title | "Role of SERCA1 truncated isoform in the proapoptotic calcium transfer from ER to mitochondria during ER stress."xsd:string |
| http://purl.uniprot.org/citations/19061639 | http://purl.uniprot.org/core/volume | "32"xsd:string |
| http://purl.uniprot.org/citations/19061639 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19061639 |
| http://purl.uniprot.org/citations/19061639 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19061639 |
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