| http://purl.uniprot.org/citations/19061864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19061864 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19061864 | http://www.w3.org/2000/01/rdf-schema#comment | "Rap2A, Rap2B, and Rap2C are Ras-like small G proteins. The role of their post-translational processing has not been investigated due to the lack of information on their downstream signaling. We have recently identified the Traf2- and Nck-interacting kinase (TNIK), a member of the STE20 group of mitogen-activated protein kinase kinase kinase kinases, as a specific Rap2 effector. Here we report that, in HEK293T cells, Rap2A (farnesylated) and Rap2C (likely farnesylated), but not Rap2B (geranylgeranylated), require palmitoylation for membrane-association and TNIK activation, whereas all Rap2 proteins, including Rap2B, require palmitoylation for induction of TNIK-mediated phenotype, the suppression of cell spreading. Furthermore, we report for the first time that, in COS-1 cells, Rap2 proteins localize, and recruit TNIK, to the recycling endosomes, but not the Golgi nor the endoplasmic reticulum, in a palmitoylation-dependent manner. These observations implicate the involvement of palmitoylation and recycling endosome localization in cellular functions of Rap2 proteins."xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2008.11.107"xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2008.11.107"xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.uniprot.org/core/author | "Endo S."xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.uniprot.org/core/author | "Endo S."xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.uniprot.org/core/author | "Takei K."xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.uniprot.org/core/author | "Takei K."xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.uniprot.org/core/author | "Taguchi T."xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.uniprot.org/core/author | "Taguchi T."xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.uniprot.org/core/author | "Kariya K."xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.uniprot.org/core/author | "Kariya K."xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.uniprot.org/core/author | "Umikawa M."xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.uniprot.org/core/author | "Umikawa M."xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.uniprot.org/core/author | "Misaki R."xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.uniprot.org/core/author | "Misaki R."xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.uniprot.org/core/author | "Yamashiro Y."xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.uniprot.org/core/author | "Yamashiro Y."xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.uniprot.org/core/author | "Oshiro M."xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.uniprot.org/core/author | "Oshiro M."xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.uniprot.org/core/author | "Asato T."xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.uniprot.org/core/author | "Asato T."xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.uniprot.org/core/author | "Bayarjargal M."xsd:string |
| http://purl.uniprot.org/citations/19061864 | http://purl.uniprot.org/core/author | "Bayarjargal M."xsd:string |