| http://purl.uniprot.org/citations/19063987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19063987 | http://www.w3.org/2000/01/rdf-schema#comment | "Gag-specific CTLs are known to have stronger ability to control HIV-1 replication than others that are protein-specific. Therefore, the analysis of Gag escape mutants is expected to clarify the mechanisms of immune control in HIV-1-infected donors. However, only a limited number of Gag escape mutants have been identified so far. A previous study suggested the possibility that Gag28-3R (KW9-3R) is an escape mutant from HLA-A*2402-restricted KW9-specific CTLs but did not show any evidence of it. Here we sought to demonstrate that KW9-3R is selected as escape mutant by KW9-specific CTLs. KW9-specific CTLs showed a remarkable reduction in recognition of target cells infected with the KW9-3R mutant. The sequence analysis of HIV-1 from 58 HIV-1-infected individuals showed that the frequency of the KW9-3R mutant was significantly higher in HLA-A*2402(+) individuals than in HLA-A*2402(-) individuals. Longitudinal analysis of an HLA-A*2402(+) individual with HIV-1 early infection showed that this escape mutant was selected over an approximately 2-year period. These results together indicate that Gag28-3R is an escape mutant selected by HLA-A*2402-restricted KW9-specific CTLs. Further analysis of this epitope will clarify the role of HIV-1-specific CTLs in the control of HIV-1 among the Japanese population, since 70% of them carry this allele."xsd:string |
| http://purl.uniprot.org/citations/19063987 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.micinf.2008.11.005"xsd:string |
| http://purl.uniprot.org/citations/19063987 | http://purl.uniprot.org/core/author | "Izumi T."xsd:string |
| http://purl.uniprot.org/citations/19063987 | http://purl.uniprot.org/core/author | "Fujiwara M."xsd:string |
| http://purl.uniprot.org/citations/19063987 | http://purl.uniprot.org/core/author | "Koizumi H."xsd:string |
| http://purl.uniprot.org/citations/19063987 | http://purl.uniprot.org/core/author | "Oka S."xsd:string |
| http://purl.uniprot.org/citations/19063987 | http://purl.uniprot.org/core/author | "Takiguchi M."xsd:string |
| http://purl.uniprot.org/citations/19063987 | http://purl.uniprot.org/core/author | "Iwatani T."xsd:string |
| http://purl.uniprot.org/citations/19063987 | http://purl.uniprot.org/core/author | "Tanuma J."xsd:string |
| http://purl.uniprot.org/citations/19063987 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19063987 | http://purl.uniprot.org/core/name | "Microbes Infect"xsd:string |
| http://purl.uniprot.org/citations/19063987 | http://purl.uniprot.org/core/pages | "198-204"xsd:string |
| http://purl.uniprot.org/citations/19063987 | http://purl.uniprot.org/core/title | "Escape mutation selected by Gag28-36-specific cytotoxic T cells in HLA-A*2402-positive HIV-1-infected donors."xsd:string |
| http://purl.uniprot.org/citations/19063987 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/19063987 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19063987 |
| http://purl.uniprot.org/citations/19063987 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19063987 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C548-mappedCitation-19063987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19063987 |
| http://purl.uniprot.org/uniprot/#_A0A0A7C551-mappedCitation-19063987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19063987 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N3-mappedCitation-19063987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19063987 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N4-mappedCitation-19063987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19063987 |
| http://purl.uniprot.org/uniprot/#_A0A0G2R0N5-mappedCitation-19063987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19063987 |
| http://purl.uniprot.org/uniprot/#_A0A076JXB7-mappedCitation-19063987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19063987 |
| http://purl.uniprot.org/uniprot/#_A0A076L0P9-mappedCitation-19063987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19063987 |
| http://purl.uniprot.org/uniprot/#_A0A0A0YLW6-mappedCitation-19063987 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19063987 |