| http://purl.uniprot.org/citations/19066201 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19066201 | http://www.w3.org/2000/01/rdf-schema#comment | "Single-stranded DNA-binding proteins (SSB) form a class of proteins that bind preferentially single-stranded DNA with high affinity. They are involved in DNA metabolism in all organisms and serve a vital role in replication, recombination and repair of DNA. In this report, we identify human mitochondrial SSB (HmtSSB) as a novel protein-binding partner of tumour suppressor p53, in mitochondria. It binds to the transactivation domain (residues 1-61) of p53 via an extended binding interface, with dissociation constant of 12.7 (+/-0.7) microM. Unlike most binding partners reported to date, HmtSSB interacts with both TAD1 (residues 1-40) and TAD2 (residues 41-61) subdomains of p53. HmtSSB enhances intrinsic 3'-5' exonuclease activity of p53, particularly in hydrolysing 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) present at 3'-end of DNA. Taken together, our data suggest that p53 is involved in DNA repair within mitochondria during oxidative stress. In addition, we characterize HmtSSB binding to ssDNA and p53 N-terminal domain using various biophysical measurements and we propose binding models for both."xsd:string |
| http://purl.uniprot.org/citations/19066201 | http://purl.org/dc/terms/identifier | "doi:10.1093/nar/gkn974"xsd:string |
| http://purl.uniprot.org/citations/19066201 | http://purl.uniprot.org/core/author | "Freund S.M."xsd:string |
| http://purl.uniprot.org/citations/19066201 | http://purl.uniprot.org/core/author | "Fersht A.R."xsd:string |
| http://purl.uniprot.org/citations/19066201 | http://purl.uniprot.org/core/author | "Rajagopalan S."xsd:string |
| http://purl.uniprot.org/citations/19066201 | http://purl.uniprot.org/core/author | "Wong T.S."xsd:string |
| http://purl.uniprot.org/citations/19066201 | http://purl.uniprot.org/core/author | "Loakes D."xsd:string |
| http://purl.uniprot.org/citations/19066201 | http://purl.uniprot.org/core/author | "Townsley F.M."xsd:string |
| http://purl.uniprot.org/citations/19066201 | http://purl.uniprot.org/core/author | "Petrovich M."xsd:string |
| http://purl.uniprot.org/citations/19066201 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19066201 | http://purl.uniprot.org/core/name | "Nucleic Acids Res"xsd:string |
| http://purl.uniprot.org/citations/19066201 | http://purl.uniprot.org/core/pages | "568-581"xsd:string |
| http://purl.uniprot.org/citations/19066201 | http://purl.uniprot.org/core/title | "Physical and functional interactions between human mitochondrial single-stranded DNA-binding protein and tumour suppressor p53."xsd:string |
| http://purl.uniprot.org/citations/19066201 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/19066201 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19066201 |
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