| http://purl.uniprot.org/citations/19070575 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19070575 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19070575 | http://www.w3.org/2000/01/rdf-schema#comment | "Kinetochore specification and assembly requires the targeted deposition of specialized nucleosomes containing the histone H3 variant CENP-A at centromeres. However, CENP-A is not sufficient to drive full-kinetochore assembly, and it is not clear how centromeric chromatin is established. Here, we identify CENP-W as a component of the DNA-proximal constitutive centromere-associated network (CCAN) of proteins. We demonstrate that CENP-W forms a DNA-binding complex together with the CCAN component CENP-T. This complex directly associates with nucleosomal DNA and with canonical histone H3, but not with CENP-A, in centromeric regions. CENP-T/CENP-W functions upstream of other CCAN components with the exception of CENP-C, an additional putative DNA-binding protein. Our analysis indicates that CENP-T/CENP-W and CENP-C provide distinct pathways to connect the centromere with outer kinetochore assembly. In total, our results suggest that the CENP-T/CENP-W complex is directly involved in establishment of centromere chromatin structure coordinately with CENP-A."xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2008.10.019"xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2008.10.019"xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.uniprot.org/core/author | "Amano M."xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.uniprot.org/core/author | "Amano M."xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.uniprot.org/core/author | "Dong Y."xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.uniprot.org/core/author | "Dong Y."xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.uniprot.org/core/author | "Suzuki A."xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.uniprot.org/core/author | "Suzuki A."xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.uniprot.org/core/author | "Hori T."xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.uniprot.org/core/author | "Hori T."xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.uniprot.org/core/author | "Suzuki E."xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.uniprot.org/core/author | "Suzuki E."xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.uniprot.org/core/author | "Cheeseman I.M."xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.uniprot.org/core/author | "Cheeseman I.M."xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.uniprot.org/core/author | "Fukagawa T."xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.uniprot.org/core/author | "Fukagawa T."xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.uniprot.org/core/author | "Okawa K."xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.uniprot.org/core/author | "Okawa K."xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.uniprot.org/core/author | "Welburn J.P."xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.uniprot.org/core/author | "Welburn J.P."xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.uniprot.org/core/author | "Backer C.B."xsd:string |
| http://purl.uniprot.org/citations/19070575 | http://purl.uniprot.org/core/author | "Backer C.B."xsd:string |