| http://purl.uniprot.org/citations/19073520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19073520 | http://www.w3.org/2000/01/rdf-schema#comment | "The insulin-receptor substrate family plays important roles in cellular growth, signaling, and survival. Two new members of this family have recently been isolated: IRS5/Dok4 and IRS6/Dok5. This study examines the expression of IRS5/DOK4 in a panel of lung cancer cell lines and tumor specimens. The results demonstrate that expression of IRS5/DOK4 is frequently altered with both elevated and decreased expression in non-small-cell lung cancer (NSCLC) tumor specimens. The altered expression of IRS5/DOK4 observed in tumor samples is not due to aberrant methylation. In vitro cell culture studies demonstrate that treatment of NSCLC cell lines with the histone deacetylase inhibitor trichostatin A (TSA) upregulates IRS5/DOK4. This finding indicates that expression is regulated epigenetically at the level of chromatin remodeling. Chromatin immunoprecipitation experiments confirm that the IRS5/DOK4 promoter has enhanced histone hyperacetylation following treatments with TSA. Finally, hypoxia was demonstrated to downregulate IRS5/DOK4 expression. This expression was restored by TSA. The clinical relevance of altered IRS5/DOK4 expression in NSCLC requires further evaluation."xsd:string |
| http://purl.uniprot.org/citations/19073520 | http://purl.org/dc/terms/identifier | "doi:10.3816/clc.2008.n.053"xsd:string |
| http://purl.uniprot.org/citations/19073520 | http://purl.uniprot.org/core/author | "Gray S.G."xsd:string |
| http://purl.uniprot.org/citations/19073520 | http://purl.uniprot.org/core/author | "O'Byrne K.J."xsd:string |
| http://purl.uniprot.org/citations/19073520 | http://purl.uniprot.org/core/author | "Baird A.M."xsd:string |
| http://purl.uniprot.org/citations/19073520 | http://purl.uniprot.org/core/author | "Gately K."xsd:string |
| http://purl.uniprot.org/citations/19073520 | http://purl.uniprot.org/core/author | "McGovern E."xsd:string |
| http://purl.uniprot.org/citations/19073520 | http://purl.uniprot.org/core/author | "Al-Sarraf N."xsd:string |
| http://purl.uniprot.org/citations/19073520 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19073520 | http://purl.uniprot.org/core/name | "Clin Lung Cancer"xsd:string |
| http://purl.uniprot.org/citations/19073520 | http://purl.uniprot.org/core/pages | "367-374"xsd:string |
| http://purl.uniprot.org/citations/19073520 | http://purl.uniprot.org/core/title | "Transcriptional regulation of IRS5/DOK4 expression in non-small-cell lung cancer cells."xsd:string |
| http://purl.uniprot.org/citations/19073520 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/19073520 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19073520 |
| http://purl.uniprot.org/citations/19073520 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19073520 |
| http://purl.uniprot.org/uniprot/#_B2RD67-mappedCitation-19073520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19073520 |
| http://purl.uniprot.org/uniprot/#_H3BQ19-mappedCitation-19073520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19073520 |
| http://purl.uniprot.org/uniprot/#_Q8TEW6-mappedCitation-19073520 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19073520 |
| http://purl.uniprot.org/uniprot/B2RD67 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19073520 |
| http://purl.uniprot.org/uniprot/Q8TEW6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19073520 |
| http://purl.uniprot.org/uniprot/H3BQ19 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19073520 |