| http://purl.uniprot.org/citations/19073596 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19073596 | http://www.w3.org/2000/01/rdf-schema#comment | "We recently presented evidence that the subunit eIF3-f of the eukaryotic initiation translation factor eIF3 that interacts with the E3-ligase Atrogin-1/muscle atrophy F-box (MAFbx) for polyubiquitination and proteasome-mediated degradation is a key target that accounts for MAFbx function during muscle atrophy. To understand this process, deletion analysis was used to identify the region of eIF3-f that is required for its proteolysis. Here, we report that the highly conserved C-terminal domain of eIF3-f is implicated for MAFbx-directed polyubiquitination and proteasomal degradation. Site-directed mutagenesis of eIF3-f revealed that the six lysine residues within this domain are required for full polyubiquitination and degradation by the proteasome. In addition, mutation of these six lysines (mutant K(5-10)R) displayed hypertrophic activity in cellulo and in vivo and was able to protect against starvation-induced muscle atrophy. Taken together, our data demonstrate that the C-terminal modifications, believed to be critical for proper eIF3-f regulation, are essential and contribute to a fine-tuning mechanism that plays an important role for eIF3-f function in skeletal muscle."xsd:string |
| http://purl.uniprot.org/citations/19073596 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m807641200"xsd:string |
| http://purl.uniprot.org/citations/19073596 | http://purl.uniprot.org/core/author | "Csibi A."xsd:string |
| http://purl.uniprot.org/citations/19073596 | http://purl.uniprot.org/core/author | "Leibovitch M.P."xsd:string |
| http://purl.uniprot.org/citations/19073596 | http://purl.uniprot.org/core/author | "Leibovitch S.A."xsd:string |
| http://purl.uniprot.org/citations/19073596 | http://purl.uniprot.org/core/author | "Tintignac L.A."xsd:string |
| http://purl.uniprot.org/citations/19073596 | http://purl.uniprot.org/core/author | "Cornille K."xsd:string |
| http://purl.uniprot.org/citations/19073596 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19073596 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/19073596 | http://purl.uniprot.org/core/pages | "4413-4421"xsd:string |
| http://purl.uniprot.org/citations/19073596 | http://purl.uniprot.org/core/title | "MAFbx/Atrogin-1 controls the activity of the initiation factor eIF3-f in skeletal muscle atrophy by targeting multiple C-terminal lysines."xsd:string |
| http://purl.uniprot.org/citations/19073596 | http://purl.uniprot.org/core/volume | "284"xsd:string |
| http://purl.uniprot.org/citations/19073596 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19073596 |
| http://purl.uniprot.org/citations/19073596 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19073596 |
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