| http://purl.uniprot.org/citations/19074312 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19074312 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19074312 | http://www.w3.org/2000/01/rdf-schema#comment | "Speciation genes restrict gene flow between the incipient species and related taxa. Three decades ago, we mapped a mammalian speciation gene, hybrid sterility 1 (Hst1), in the intersubspecific hybrids of house mouse. Here, we identify this gene as Prdm9, encoding a histone H3 lysine 4 trimethyltransferase. We rescued infertility in male hybrids with bacterial artificial chromosomes carrying Prdm9 from a strain with the "fertility" Hst1(f) allele. Sterile hybrids display down-regulated microrchidia 2B (Morc2b) and fail to compartmentalize gammaH2AX into the pachynema sex (XY) body. These defects, seen also in Prdm9-null mutants, are rescued by the Prdm9 transgene. Identification of a vertebrate hybrid sterility gene reveals a role for epigenetics in speciation and opens a window to a hybrid sterility gene network."xsd:string |
| http://purl.uniprot.org/citations/19074312 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1163601"xsd:string |
| http://purl.uniprot.org/citations/19074312 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1163601"xsd:string |
| http://purl.uniprot.org/citations/19074312 | http://purl.uniprot.org/core/author | "Vlcek C."xsd:string |
| http://purl.uniprot.org/citations/19074312 | http://purl.uniprot.org/core/author | "Vlcek C."xsd:string |
| http://purl.uniprot.org/citations/19074312 | http://purl.uniprot.org/core/author | "Forejt J."xsd:string |
| http://purl.uniprot.org/citations/19074312 | http://purl.uniprot.org/core/author | "Forejt J."xsd:string |
| http://purl.uniprot.org/citations/19074312 | http://purl.uniprot.org/core/author | "Schimenti J.C."xsd:string |
| http://purl.uniprot.org/citations/19074312 | http://purl.uniprot.org/core/author | "Schimenti J.C."xsd:string |
| http://purl.uniprot.org/citations/19074312 | http://purl.uniprot.org/core/author | "Trachtulec Z."xsd:string |
| http://purl.uniprot.org/citations/19074312 | http://purl.uniprot.org/core/author | "Trachtulec Z."xsd:string |
| http://purl.uniprot.org/citations/19074312 | http://purl.uniprot.org/core/author | "Mihola O."xsd:string |
| http://purl.uniprot.org/citations/19074312 | http://purl.uniprot.org/core/author | "Mihola O."xsd:string |
| http://purl.uniprot.org/citations/19074312 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19074312 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19074312 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/19074312 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/19074312 | http://purl.uniprot.org/core/pages | "373-375"xsd:string |
| http://purl.uniprot.org/citations/19074312 | http://purl.uniprot.org/core/pages | "373-375"xsd:string |
| http://purl.uniprot.org/citations/19074312 | http://purl.uniprot.org/core/title | "A mouse speciation gene encodes a meiotic histone H3 methyltransferase."xsd:string |
| http://purl.uniprot.org/citations/19074312 | http://purl.uniprot.org/core/title | "A mouse speciation gene encodes a meiotic histone H3 methyltransferase."xsd:string |
| http://purl.uniprot.org/citations/19074312 | http://purl.uniprot.org/core/volume | "323"xsd:string |
| http://purl.uniprot.org/citations/19074312 | http://purl.uniprot.org/core/volume | "323"xsd:string |