| http://purl.uniprot.org/citations/19074353 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19074353 | http://www.w3.org/2000/01/rdf-schema#comment | "Dendritic cells (DCs) sample peripheral tissues of the body in search of antigens to present to T cells. This requires two processes, antigen processing and cell motility, originally thought to occur independently. We found that the major histocompatibility complex II-associated invariant chain (Ii or CD74), a known regulator of antigen processing, negatively regulates DC motility in vivo. By using microfabricated channels to mimic the confined environment of peripheral tissues, we found that wild-type DCs alternate between high and low motility, whereas Ii-deficient cells moved in a faster and more uniform manner. The regulation of cell motility by Ii depended on the actin-based motor protein myosin II. Coupling antigen processing and cell motility may enable DCs to more efficiently detect and process antigens within a defined space."xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1159894"xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/author | "Diaz J."xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/author | "Raposo G."xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/author | "Rosemblatt M."xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/author | "Vascotto F."xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/author | "Vargas P."xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/author | "Lennon-Dumenil A.M."xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/author | "Boulanger J."xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/author | "Piel M."xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/author | "Yuseff M.I."xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/author | "Manry J."xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/author | "Hugues S."xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/author | "Bono M.R."xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/author | "Lankar D."xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/author | "Faure-Andre G."xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/author | "Heuze M."xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/author | "Steri V."xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/pages | "1705-1710"xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/title | "Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain."xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://purl.uniprot.org/core/volume | "322"xsd:string |
| http://purl.uniprot.org/citations/19074353 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19074353 |