| http://purl.uniprot.org/citations/19075002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19075002 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19075002 | http://www.w3.org/2000/01/rdf-schema#comment | "Aurora-A is a conserved kinase implicated in mitotic regulation and carcinogenesis. Aurora-A was previously implicated in mitotic entry and spindle assembly, although contradictory results prevented a clear understanding of the roles of Aurora-A in mammals. We developed a conditional null mutation in the mouse Aurora-A gene to investigate Aurora-A functions in primary cells ex vivo and in vivo. We show here that conditional Aurora-A ablation in cultured embryonic fibroblasts causes impaired mitotic entry and mitotic arrest with a profound defect in bipolar spindle formation. Germ line Aurora-A deficiency causes embryonic death at the blastocyst stage with pronounced cell proliferation failure, mitotic arrest, and monopolar spindle formation. Aurora-A deletion in mid-gestation embryos causes an increase in mitotic and apoptotic cells. These results indicate that murine Aurora-A facilitates, but is not absolutely required for, mitotic entry in murine embryonic fibroblasts and is essential for centrosome separation and bipolar spindle formation in vitro and in vivo. Aurora-A deletion increases apoptosis, suggesting that molecular therapies targeting Aurora-A may be effective in inducing tumor cell apoptosis. Aurora-A conditional mutant mice provide a valuable system for further defining Aurora-A functions and for predicting effects of Aurora-A therapeutic intervention."xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01062-08"xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01062-08"xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.uniprot.org/core/author | "Lu L."xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.uniprot.org/core/author | "Lu L."xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.uniprot.org/core/author | "Magnuson T."xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.uniprot.org/core/author | "Magnuson T."xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.uniprot.org/core/author | "He Y.J."xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.uniprot.org/core/author | "He Y.J."xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.uniprot.org/core/author | "Salmon E.D."xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.uniprot.org/core/author | "Salmon E.D."xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.uniprot.org/core/author | "Cowley D.O."xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.uniprot.org/core/author | "Cowley D.O."xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.uniprot.org/core/author | "O'Quinn R."xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.uniprot.org/core/author | "O'Quinn R."xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.uniprot.org/core/author | "Oliver T.G."xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.uniprot.org/core/author | "Oliver T.G."xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.uniprot.org/core/author | "Rivera-Perez J.A."xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.uniprot.org/core/author | "Rivera-Perez J.A."xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.uniprot.org/core/author | "Schliekelman M."xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.uniprot.org/core/author | "Schliekelman M."xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.uniprot.org/core/author | "Van Dyke T."xsd:string |
| http://purl.uniprot.org/citations/19075002 | http://purl.uniprot.org/core/author | "Van Dyke T."xsd:string |