| http://purl.uniprot.org/citations/19075109 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19075109 | http://www.w3.org/2000/01/rdf-schema#comment | "Alpha-epithelial catenin (E-catenin) is an important cell-cell adhesion protein. In this study, we show that alpha-E-catenin also regulates intracellular traffic by binding to the dynactin complex component dynamitin. Dynactin-mediated organelle trafficking is increased in alpha-E-catenin(-/-) keratinocytes, an effect that is reversed by expression of exogenous alpha-E-catenin. Disruption of adherens junctions in low-calcium media does not affect dynactin-mediated traffic, indicating that alpha-E-catenin regulates traffic independently from its function in cell-cell adhesion. Although neither the integrity of dynactin-dynein complexes nor their association with vesicles is affected by alpha-E-catenin, alpha-E-catenin is necessary for the attenuation of microtubule-dependent trafficking by the actin cytoskeleton. Because the actin-binding domain of alpha-E-catenin is necessary for this regulation, we hypothesize that alpha-E-catenin functions as a dynamic link between the dynactin complex and actin and, thus, integrates the microtubule and actin cytoskeleton during intracellular trafficking."xsd:string |
| http://purl.uniprot.org/citations/19075109 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200805041"xsd:string |
| http://purl.uniprot.org/citations/19075109 | http://purl.uniprot.org/core/author | "Gelfand V.I."xsd:string |
| http://purl.uniprot.org/citations/19075109 | http://purl.uniprot.org/core/author | "Vasioukhin V."xsd:string |
| http://purl.uniprot.org/citations/19075109 | http://purl.uniprot.org/core/author | "Lien W.H."xsd:string |
| http://purl.uniprot.org/citations/19075109 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19075109 | http://purl.uniprot.org/core/name | "J Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/19075109 | http://purl.uniprot.org/core/pages | "989-997"xsd:string |
| http://purl.uniprot.org/citations/19075109 | http://purl.uniprot.org/core/title | "Alpha-E-catenin binds to dynamitin and regulates dynactin-mediated intracellular traffic."xsd:string |
| http://purl.uniprot.org/citations/19075109 | http://purl.uniprot.org/core/volume | "183"xsd:string |
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