| http://purl.uniprot.org/citations/19076073 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19076073 | http://www.w3.org/2000/01/rdf-schema#comment | "In the blood plasma of humans and rats, ceruloplasmin is the major copper-binding protein and ferroxidase, accounting for 70% of the copper present in the plasma, with the rest binding primarily to albumin and a macroglobulin. Systematic studies with fresh plasma were carried out to compare what occurs in the mouse. C57BL6 mice had half as much copper and pPD (p-phenylene diamine) oxidase activity as humans and rats, 20-40% as much ferroxidase activity as humans (determined using three different assays) and less inhibition by azide. Plasma from ceruloplasmin knockout mice had no pPD oxidase activity, but retained >50% ferroxidase activity (which was not as affected by azide). Modelling of mouse ceruloplasmin against the known X-ray structure of human ceruloplasmin indicated subtle but potentially significant changes in the pPD- and azide-binding sites. Purification and in-gel assays after native PAGE confirmed that mouse ceruloplasmin had ferroxidase activity but revealed an additional ferroxidase in ceruloplasmin knockout mouse plasma, which is also seen in size-exclusion chromatography. In the wild-type mouse, the 'ceruloplasmin' peak contained approximately 55% of the total copper, but ceruloplasmin knockout plasma exposed a major additional peak (180 kDa) which co-eluted with ferroxidase activity. Two other ferroxidases (700 and 2000 Da) were also detected in mouse and human plasma. Mammalian blood thus contains copper components and ferroxidases not reported previously."xsd:string |
| http://purl.uniprot.org/citations/19076073 | http://purl.org/dc/terms/identifier | "doi:10.1042/bj20081983"xsd:string |
| http://purl.uniprot.org/citations/19076073 | http://purl.uniprot.org/core/author | "Nguyen A."xsd:string |
| http://purl.uniprot.org/citations/19076073 | http://purl.uniprot.org/core/author | "Chu Y.L."xsd:string |
| http://purl.uniprot.org/citations/19076073 | http://purl.uniprot.org/core/author | "Akagi S."xsd:string |
| http://purl.uniprot.org/citations/19076073 | http://purl.uniprot.org/core/author | "Cabrera A."xsd:string |
| http://purl.uniprot.org/citations/19076073 | http://purl.uniprot.org/core/author | "Kantardjieff K."xsd:string |
| http://purl.uniprot.org/citations/19076073 | http://purl.uniprot.org/core/author | "Linder M.C."xsd:string |
| http://purl.uniprot.org/citations/19076073 | http://purl.uniprot.org/core/author | "Gray L.W."xsd:string |
| http://purl.uniprot.org/citations/19076073 | http://purl.uniprot.org/core/author | "Kidane T.Z."xsd:string |
| http://purl.uniprot.org/citations/19076073 | http://purl.uniprot.org/core/author | "Mason A.Z."xsd:string |
| http://purl.uniprot.org/citations/19076073 | http://purl.uniprot.org/core/author | "Petrasek K."xsd:string |
| http://purl.uniprot.org/citations/19076073 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19076073 | http://purl.uniprot.org/core/name | "Biochem J"xsd:string |
| http://purl.uniprot.org/citations/19076073 | http://purl.uniprot.org/core/pages | "237-245"xsd:string |
| http://purl.uniprot.org/citations/19076073 | http://purl.uniprot.org/core/title | "Copper proteins and ferroxidases in human plasma and that of wild-type and ceruloplasmin knockout mice."xsd:string |
| http://purl.uniprot.org/citations/19076073 | http://purl.uniprot.org/core/volume | "419"xsd:string |
| http://purl.uniprot.org/citations/19076073 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19076073 |
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