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http://purl.uniprot.org/citations/19076333http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19076333http://www.w3.org/2000/01/rdf-schema#comment"

Background and objectives

In the Rh blood group system, partial D, C, and e antigens are well-known, but a partial c antigen resulting in the production of alloanti-c in a c+ individual is rare. One example of an alloanti-c in a c+ person was an anti-Rh26, which can appear as anti-c, and another was an alloanti-c in a c+ person with a presumed R(1)r phenotype. The finding of an apparent alloanti-c in a transfused c+ patient initiated this investigation.

Materials and methods

Haemagglutination tests, DNA extraction, polymerase chain reaction (PCR)-based assays (PCR-restriction fragment length polymorphism, allele-specific PCR), reticulocyte mRNA extraction, reverse transcriptase (RT)-PCR and sequencing were performed by standard procedures.

Results

Plasma from a 64-year-old African American woman with a wound infection following a mastectomy contained anti-E, anti-S, anti-K, anti-Fy(a) and anti-Jk(b), reacting by the indirect antiglobulin test. In addition, the patient's plasma gave reactions that were consistent with an anti-c, while her pre-transfusion red blood cells typed c+ with some anti-c reagents. These results are consistent with a partial c antigen. The patient's red blood cells also typed V+(W)VS- and JAL+. Analyses of DNA and Rh-transcripts from this patient showed the presence of the following genes: RHD*D, RHD*DAU0, RHCE*Ce and RHCE*ce(S)(340).

Conclusion

The nucleotide 340C>T change in RHCE exon 3 (predicted to encode 114Trp) of the RHCE*ce(S)(340) allele is associated with a JAL+ phenotype and the altered expression of the c, V and VS antigens. This alteration in the c antigen allowed the patient to make an alloanti-c. This case reveals that the RHCE*ce(S)(340) allele encodes a partial c antigen."xsd:string
http://purl.uniprot.org/citations/19076333http://purl.org/dc/terms/identifier"doi:10.1111/j.1423-0410.2008.01135.x"xsd:string
http://purl.uniprot.org/citations/19076333http://purl.uniprot.org/core/author"Reid M.E."xsd:string
http://purl.uniprot.org/citations/19076333http://purl.uniprot.org/core/author"Storry J.R."xsd:string
http://purl.uniprot.org/citations/19076333http://purl.uniprot.org/core/author"Ong J."xsd:string
http://purl.uniprot.org/citations/19076333http://purl.uniprot.org/core/author"Lomas-Francis C."xsd:string
http://purl.uniprot.org/citations/19076333http://purl.uniprot.org/core/author"Vege S."xsd:string
http://purl.uniprot.org/citations/19076333http://purl.uniprot.org/core/author"Westhoff C."xsd:string
http://purl.uniprot.org/citations/19076333http://purl.uniprot.org/core/author"Schmulbach E."xsd:string
http://purl.uniprot.org/citations/19076333http://purl.uniprot.org/core/author"Walker P.S."xsd:string
http://purl.uniprot.org/citations/19076333http://purl.uniprot.org/core/date"2009"xsd:gYear
http://purl.uniprot.org/citations/19076333http://purl.uniprot.org/core/name"Vox Sang"xsd:string
http://purl.uniprot.org/citations/19076333http://purl.uniprot.org/core/pages"240-243"xsd:string
http://purl.uniprot.org/citations/19076333http://purl.uniprot.org/core/title"Alloanti-c in a c-positive, JAL-positive patient."xsd:string
http://purl.uniprot.org/citations/19076333http://purl.uniprot.org/core/volume"96"xsd:string
http://purl.uniprot.org/citations/19076333http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19076333
http://purl.uniprot.org/citations/19076333http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19076333
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http://purl.uniprot.org/uniprot/#_A0A078BQE0-mappedCitation-19076333http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/19076333
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