| http://purl.uniprot.org/citations/19079180 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19079180 | http://www.w3.org/2000/01/rdf-schema#comment | "In a nasal vaccine against influenza, the activation of natural killer T (NKT) cells by intranasal coadministration of alpha-galactosylceramide (alpha-GalCer) can potently enhance protective immune responses. The results of this study show that the NKT cell-activated nasal vaccine can induce an effective cross-protection against different strains of influenza virus, including H5 type. To analyze the mechanism of NKT cell activation by this nasal vaccine, we prepared fluorescence-labeled alpha-GalCer by which we detect a direct interaction between NKT cells and alpha-GalCer-stored dendritic cells in nasal mucosa-associated tissues. Accordingly, although very few NKT cells exist at mucosa, the nasal vaccination induced a localized increase in NKT cell population, which is partly dependent on CXCL16/CXCR6. Furthermore, we found that NKT cell activation stimulates mucosal IgA production by a mechanism that is dependent on interleukin (IL)-4 production. These results strengthen the basis of nasal vaccination via NKT cell activation, which can induce immune cross-protection."xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.org/dc/terms/identifier | "doi:10.1038/mi.2008.2"xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/author | "Jiang X."xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/author | "Mori K."xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/author | "Ohno H."xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/author | "Nagata Y."xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/author | "Odagiri T."xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/author | "Taniguchi M."xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/author | "Tashiro M."xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/author | "Yonehara S."xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/author | "Sata T."xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/author | "Hase K."xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/author | "Hasegawa H."xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/author | "Tashiro T."xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/author | "Ichinohe T."xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/author | "Shimaoka T."xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/author | "Seino K.I."xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/author | "Kamijuku H."xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/name | "Mucosal Immunol"xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/pages | "208-218"xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/title | "Mechanism of NKT cell activation by intranasal coadministration of alpha-galactosylceramide, which can induce cross-protection against influenza viruses."xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://purl.uniprot.org/core/volume | "1"xsd:string |
| http://purl.uniprot.org/citations/19079180 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19079180 |