| http://purl.uniprot.org/citations/19088195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19088195 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor E2F-1 drives proliferation and death, but the mechanisms that differentially regulate these divergent actions are poorly understood. The hypoxia-inducible death factor Bnip3 is an E2F-1 target gene and integral component of the intrinsic mitochondrial death pathway. The mechanisms that govern Bnip3 gene activity remain cryptic. Herein we show that the transcription factor NF-kappaB provides a molecular switch that determines whether E2F-1 signals proliferation or death under physiological conditions. We show under basal nonapoptotic conditions that NF-kappaB constitutively occupies and transcriptionally silences Bnip3 gene transcription by competing with E2F-1 for Bnip3 promoter binding. Conversely, in the absence of NF-kappaB, or during hypoxia when NF-kappaB abundance is reduced, basal Bnip3 gene transcription is activated by the unrestricted binding of E2F-1 to the Bnip3 promoter. Genetic knock-down of E2F-1 or retinoblastoma gene product over-expression in cardiac and human pancreatic cancer cells deficient for NF-kappaB signaling abrogated basal and hypoxia-inducible Bnip3 transcription. The survival kinase PI3K/Akt inhibited Bnip3 expression levels in cells in a manner dependent upon NF-kappaB activation. Hence, by way of example, we show that the transcriptional inhibition of E2F-1-dependent Bnip3 expression by NF-kappaB highlights a survival pathway that overrides the E2F-1 tumor suppressor program. Our data may explain more fundamentally how cells, by selectively inhibiting E2F-1-dependent death gene transcription, avert apoptosis down-stream of the retinoblastoma/E2F-1 cell cycle pathway."xsd:string |
| http://purl.uniprot.org/citations/19088195 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0807735105"xsd:string |
| http://purl.uniprot.org/citations/19088195 | http://purl.uniprot.org/core/author | "Zhang T."xsd:string |
| http://purl.uniprot.org/citations/19088195 | http://purl.uniprot.org/core/author | "Shaw J."xsd:string |
| http://purl.uniprot.org/citations/19088195 | http://purl.uniprot.org/core/author | "Yurkova N."xsd:string |
| http://purl.uniprot.org/citations/19088195 | http://purl.uniprot.org/core/author | "Aguilar F."xsd:string |
| http://purl.uniprot.org/citations/19088195 | http://purl.uniprot.org/core/author | "Gang H."xsd:string |
| http://purl.uniprot.org/citations/19088195 | http://purl.uniprot.org/core/author | "Kirshenbaum L.A."xsd:string |
| http://purl.uniprot.org/citations/19088195 | http://purl.uniprot.org/core/author | "Weidman D."xsd:string |
| http://purl.uniprot.org/citations/19088195 | http://purl.uniprot.org/core/author | "Scramstad C."xsd:string |
| http://purl.uniprot.org/citations/19088195 | http://purl.uniprot.org/core/author | "Weisman H."xsd:string |
| http://purl.uniprot.org/citations/19088195 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19088195 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/19088195 | http://purl.uniprot.org/core/pages | "20734-20739"xsd:string |
| http://purl.uniprot.org/citations/19088195 | http://purl.uniprot.org/core/title | "Antagonism of E2F-1 regulated Bnip3 transcription by NF-kappaB is essential for basal cell survival."xsd:string |
| http://purl.uniprot.org/citations/19088195 | http://purl.uniprot.org/core/volume | "105"xsd:string |
| http://purl.uniprot.org/citations/19088195 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19088195 |
| http://purl.uniprot.org/citations/19088195 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19088195 |
| http://purl.uniprot.org/uniprot/O09139#attribution-8BEA00983B71A205BB4A1402B0502C56 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19088195 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JWW3-mappedCitation-19088195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19088195 |
| http://purl.uniprot.org/uniprot/#_A0A8L2QBV4-mappedCitation-19088195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19088195 |
| http://purl.uniprot.org/uniprot/#_A0A2U8ZU93-mappedCitation-19088195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19088195 |
| http://purl.uniprot.org/uniprot/#_B4DHJ7-mappedCitation-19088195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19088195 |
| http://purl.uniprot.org/uniprot/#_F7FHM5-mappedCitation-19088195 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19088195 |