| http://purl.uniprot.org/citations/1908951 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1908951 | http://www.w3.org/2000/01/rdf-schema#comment | "The number of lymphocytes in an animal is remarkably constant despite antigen-driven proliferation and a high rate of B-cell lymphopoiesis. This reflects the relatively brief lifespan of many newly generated B cells and argues for a well-regulated death mechanism. Even so, a secondary immune response can be generated years after a primary exposure to antigen. Antigen that might restimulate B cells persists for extended periods on follicular dendritic cells in the light zone of germinal centres. Antigen-binding B cells have also been found months after the end of obvious cell division. The precise signal that enables certain B cells to emerge as long-term surviving memory cells is unknown. Bcl-2, an inner mitochondrial membrane protein, blocks programmed cell death in B cells. We report here that this proto-oncogene maintains immune responsiveness. Transgenic mice overproducing Bcl-2 have a long-term persistence of immunoglobulin-secreting cells and an extended lifetime for memory B cells."xsd:string |
| http://purl.uniprot.org/citations/1908951 | http://purl.org/dc/terms/identifier | "doi:10.1038/353071a0"xsd:string |
| http://purl.uniprot.org/citations/1908951 | http://purl.uniprot.org/core/author | "Nunez G."xsd:string |
| http://purl.uniprot.org/citations/1908951 | http://purl.uniprot.org/core/author | "Korsmeyer S.J."xsd:string |
| http://purl.uniprot.org/citations/1908951 | http://purl.uniprot.org/core/author | "Hockenbery D."xsd:string |
| http://purl.uniprot.org/citations/1908951 | http://purl.uniprot.org/core/author | "Sorensen C.M."xsd:string |
| http://purl.uniprot.org/citations/1908951 | http://purl.uniprot.org/core/author | "McDonnell T.J."xsd:string |
| http://purl.uniprot.org/citations/1908951 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/1908951 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/1908951 | http://purl.uniprot.org/core/pages | "71-73"xsd:string |
| http://purl.uniprot.org/citations/1908951 | http://purl.uniprot.org/core/title | "Bcl-2 maintains B cell memory."xsd:string |
| http://purl.uniprot.org/citations/1908951 | http://purl.uniprot.org/core/volume | "353"xsd:string |
| http://purl.uniprot.org/citations/1908951 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1908951 |
| http://purl.uniprot.org/citations/1908951 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1908951 |
| http://purl.uniprot.org/uniprot/P10415#attribution-9B7DB9E8105CFFBD0430512386F2BE56 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/1908951 |