| http://purl.uniprot.org/citations/19091860 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19091860 | http://www.w3.org/2000/01/rdf-schema#comment | "We have previously reported on the ubiquitylation and degradation of hepatitis C virus core protein. Here we demonstrate that proteasomal degradation of the core protein is mediated by two distinct mechanisms. One leads to polyubiquitylation, in which lysine residues in the N-terminal region are preferential ubiquitylation sites. The other is independent of the presence of ubiquitin. Gain- and loss-of-function analyses using lysineless mutants substantiate the hypothesis that the proteasome activator PA28gamma, a binding partner of the core, is involved in the ubiquitin-independent degradation of the core protein. Our results suggest that turnover of this multifunctional viral protein can be tightly controlled via dual ubiquitin-dependent and -independent proteasomal pathways."xsd:string |
| http://purl.uniprot.org/citations/19091860 | http://purl.org/dc/terms/identifier | "doi:10.1128/jvi.01690-08"xsd:string |
| http://purl.uniprot.org/citations/19091860 | http://purl.uniprot.org/core/author | "Fukuda K."xsd:string |
| http://purl.uniprot.org/citations/19091860 | http://purl.uniprot.org/core/author | "Ishii K."xsd:string |
| http://purl.uniprot.org/citations/19091860 | http://purl.uniprot.org/core/author | "Matsuura Y."xsd:string |
| http://purl.uniprot.org/citations/19091860 | http://purl.uniprot.org/core/author | "Miyamura T."xsd:string |
| http://purl.uniprot.org/citations/19091860 | http://purl.uniprot.org/core/author | "Moriishi K."xsd:string |
| http://purl.uniprot.org/citations/19091860 | http://purl.uniprot.org/core/author | "Suzuki T."xsd:string |
| http://purl.uniprot.org/citations/19091860 | http://purl.uniprot.org/core/author | "Suzuki R."xsd:string |
| http://purl.uniprot.org/citations/19091860 | http://purl.uniprot.org/core/author | "Wakita T."xsd:string |
| http://purl.uniprot.org/citations/19091860 | http://purl.uniprot.org/core/author | "Shirakura M."xsd:string |
| http://purl.uniprot.org/citations/19091860 | http://purl.uniprot.org/core/author | "Shoji I."xsd:string |
| http://purl.uniprot.org/citations/19091860 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19091860 | http://purl.uniprot.org/core/name | "J Virol"xsd:string |
| http://purl.uniprot.org/citations/19091860 | http://purl.uniprot.org/core/pages | "2389-2392"xsd:string |
| http://purl.uniprot.org/citations/19091860 | http://purl.uniprot.org/core/title | "Proteasomal turnover of hepatitis C virus core protein is regulated by two distinct mechanisms: a ubiquitin-dependent mechanism and a ubiquitin-independent but PA28gamma-dependent mechanism."xsd:string |
| http://purl.uniprot.org/citations/19091860 | http://purl.uniprot.org/core/volume | "83"xsd:string |
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| http://purl.uniprot.org/uniprot/#_P61289-mappedCitation-19091860 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19091860 |