| http://purl.uniprot.org/citations/19091958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19091958 | http://www.w3.org/2000/01/rdf-schema#comment | "During apoptosis, proteolytic cleavage of Bax at the amino terminus generates a truncated Bax of approximately 18 kDa (p18Bax) and an amino-terminal peptide of approximately 3 kDa (p3Bax). Whereas extensive studies have shown that p18Bax behaves like a BH3 protein with enhanced pro-apoptotic function over that of the full-length Bax (p21Bax), little is known about the function of p3Bax in apoptosis. We have previously shown that Bax and Ca2+ play a synergistic role in amplifying apoptosis signaling and that store-operated Ca2+ entry (SOCE) contributes to Bax-mediated apoptosis in prostate cancer cells. Here we test whether p3Bax can contribute to regulation of Ca2+ signaling during apoptosis through use of a membrane-penetrating peptide to facilitate delivery of recombinant p3Bax into NRP-154 cells, a prostate epithelial cell line with tumorigenic capacity. We find that human immunodefficiency virus transactivator of transcription protein (TAT)-p3Bax fusion peptide can enhance thapsigargin-induced apoptosis in NRP-154 cells, elevate SOCE activity, and increase inositol 1,4,5-trisphosphate-sensitive intracellular Ca2+ stores. Our data indicates that p3Bax can modulate the entry of extracellular Ca2+ and thus regulate the amplification of apoptosis in prostate cancer cells."xsd:string |
| http://purl.uniprot.org/citations/19091958 | http://purl.org/dc/terms/identifier | "doi:10.1152/ajpcell.00390.2008"xsd:string |
| http://purl.uniprot.org/citations/19091958 | http://purl.uniprot.org/core/author | "Li N."xsd:string |
| http://purl.uniprot.org/citations/19091958 | http://purl.uniprot.org/core/author | "Ma J."xsd:string |
| http://purl.uniprot.org/citations/19091958 | http://purl.uniprot.org/core/author | "Pan Z."xsd:string |
| http://purl.uniprot.org/citations/19091958 | http://purl.uniprot.org/core/author | "Cai C."xsd:string |
| http://purl.uniprot.org/citations/19091958 | http://purl.uniprot.org/core/author | "Lin P."xsd:string |
| http://purl.uniprot.org/citations/19091958 | http://purl.uniprot.org/core/author | "Weisleder N."xsd:string |
| http://purl.uniprot.org/citations/19091958 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19091958 | http://purl.uniprot.org/core/name | "Am J Physiol Cell Physiol"xsd:string |
| http://purl.uniprot.org/citations/19091958 | http://purl.uniprot.org/core/pages | "C267-72"xsd:string |
| http://purl.uniprot.org/citations/19091958 | http://purl.uniprot.org/core/title | "The amino-terminal peptide of Bax perturbs intracellular Ca2+ homeostasis to enhance apoptosis in prostate cancer cells."xsd:string |
| http://purl.uniprot.org/citations/19091958 | http://purl.uniprot.org/core/volume | "296"xsd:string |
| http://purl.uniprot.org/citations/19091958 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19091958 |
| http://purl.uniprot.org/citations/19091958 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19091958 |
| http://purl.uniprot.org/uniprot/#_A0A165ELP6-mappedCitation-19091958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19091958 |
| http://purl.uniprot.org/uniprot/#_Q07813-mappedCitation-19091958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19091958 |
| http://purl.uniprot.org/uniprot/#_Q3TXJ7-mappedCitation-19091958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19091958 |
| http://purl.uniprot.org/uniprot/#_Q8K3J2-mappedCitation-19091958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19091958 |
| http://purl.uniprot.org/uniprot/#_Q544Z6-mappedCitation-19091958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19091958 |
| http://purl.uniprot.org/uniprot/#_Q8VHY7-mappedCitation-19091958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19091958 |
| http://purl.uniprot.org/uniprot/#_Q9R0K9-mappedCitation-19091958 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19091958 |
| http://purl.uniprot.org/uniprot/A0A165ELP6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19091958 |
| http://purl.uniprot.org/uniprot/Q9R0K9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/19091958 |