| http://purl.uniprot.org/citations/19092120 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19092120 | http://www.w3.org/2000/01/rdf-schema#comment | "Depletion of podocytes, common to glomerular diseases in general, plays a role in the pathogenesis of glomerulosclerosis. Whether podocyte injury in adulthood can be repaired has not been established. Here, we demonstrate that in the adult human kidney, CD133+CD24+ cells consist of a hierarchical population of progenitors that are arranged in a precise sequence within Bowman's capsule and exhibit heterogeneous potential for differentiation and regeneration. Cells localized to the urinary pole that expressed CD133 and CD24, but not podocyte markers (CD133+CD24+PDX-cells), could regenerate both tubular cells and podocytes. In contrast, cells localized between the urinary pole and vascular pole that expressed both progenitor and podocytes markers (CD133+CD24+PDX+) could regenerate only podocytes. Finally, cells localized to the vascular pole did not exhibit progenitor markers, but displayed phenotypic features of differentiated podocytes (CD133-CD24-PDX+ cells). Injection of CD133+CD24+PDX-cells, but not CD133+CD24+PDX+ or CD133-CD24-cells, into mice with adriamycin-induced nephropathy reduced proteinuria and improved chronic glomerular damage, suggesting that CD133+CD24+PDX-cells could potentially treat glomerular disorders characterized by podocyte injury, proteinuria, and progressive glomerulosclerosis."xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.org/dc/terms/identifier | "doi:10.1681/asn.2008070709"xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/author | "Serio M."xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/author | "Lasagni L."xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/author | "Lazzeri E."xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/author | "Maggi E."xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/author | "Mazzinghi B."xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/author | "Romagnani P."xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/author | "Romagnani S."xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/author | "Sagrinati C."xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/author | "Parente E."xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/author | "Carini M."xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/author | "Vannelli G.B."xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/author | "Gacci M."xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/author | "Ballerini L."xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/author | "Ronconi E."xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/author | "Angelotti M.L."xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/author | "Becherucci F."xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/name | "J Am Soc Nephrol"xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/pages | "322-332"xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/title | "Regeneration of glomerular podocytes by human renal progenitors."xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/19092120 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19092120 |