| http://purl.uniprot.org/citations/19094966 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19094966 | http://www.w3.org/2000/01/rdf-schema#comment | "Angiopoietin-like protein family 4 (Angptl 4) has been shown to regulate lipoprotein metabolism through the inhibition of lipoprotein lipase (LPL). We generated ApoE(-/-)Angptl 4(-/-) mice to study the effect of Angptl 4 deficiency on lipid metabolism and atherosclerosis. Fasting and postolive oil-loaded triglyceride (TG) levels were largely decreased in ApoE(-/-)Angptl 4(-/-) mice compared with and ApoE(-/-)Angptl 4(+/+) mice. There was a significant (75+/-12%) reduction in atherosclerotic lesion size in ApoE(-/-)Angptl 4(-/-) mice compared with ApoE(-/-) Angptl 4(+/+) mice. Peritoneal macrophages, isolated from Angptl 4(-/-) mice to investigate the foam cell formation, showed a significant decrease in newly synthesized cholesteryl ester (CE) accumulation induced by acetyl low-density lipoprotein (acLDL) compared with those from Angptl 4(+/+) mice. Thus, genetic knockout of Angptl 4 protects ApoE(-/-) mice against development and progression of atherosclerosis and strongly suppresses the ability of the macrophages to become foam cells in vitro."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.bbrc.2008.12.018"xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Fujiwara Y."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Ishii N."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Miyata K."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Nishikawa T."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Takeya M."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Yamashita S."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Adachi H."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Kondo T."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Motoshima H."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Suda T."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Matsumura T."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Ogawa R."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Oike Y."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Nagy A."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Nagai R."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Koh G.Y."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Tabata M."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Araki E."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Furukawa N."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Tsuruzoe K."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/author | "Kawashima J."xsd:string |
| http://purl.uniprot.org/citations/19094966 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |