| http://purl.uniprot.org/citations/19095286 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19095286 | http://www.w3.org/2000/01/rdf-schema#comment | "Enantioselectivity in the separation, toxicology, biodegradation and estrogenic activity of chiral pesticides has become a groundbreaking topic recently. In this study, real-time, quantitative polymerase chain reaction was adapted to investigate the induction of estrogen-responsive gene expression in embryo-larval zebrafish after 7 d of exposure to permethrin (PM) enantiomers. The PM enantiomers were completely separated by a chiral HPLC column. The in vivo study found that a 7 d exposure to 250 ng L(-1) PM racemate and its enantiomers was sufficient to stimulate vtg1, esralpha and cyp19b expression, while 1000 ng L(-1) exposure significantly induced gene expression in a pattern similar to that of the control (50 ng L(-1) E2), except for vtg2. Significant differences were detected between the enantiomers in the induction of estrogen-responsive gene expression. At the exposure level of 1000 ng L(-1), the vtg1, esralpha and cyp19b responses to the (-)-trans enantiomer were about 3.2-, 1.8- and 1.5-fold higher, respectively, than those in the group treated with (+)-trans enantiomer (p < 0.05). In the two cis-enantiomer treatment groups, (+)-cis increased the mRNA level of the cyp19b gene about 1.5-fold higher than the (-)-cis-enantiomer did. Of the four enantiomers, the (-)-trans enantiomer showed the greatest estrogenic activity. The results strongly indicate the occurrence of significant enantioselectivity in estrogenic activity of PM enantiomers exposed to embryo-larval zebrafish. These findings add to a growing body of evidence concerning enantioselectivity in the toxicity, endocrine-disrupting activity, and environmental biodegradation of chiral pesticides."xsd:string |
| http://purl.uniprot.org/citations/19095286 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.chemosphere.2008.11.015"xsd:string |
| http://purl.uniprot.org/citations/19095286 | http://purl.uniprot.org/core/author | "Chen R."xsd:string |
| http://purl.uniprot.org/citations/19095286 | http://purl.uniprot.org/core/author | "Fu Z."xsd:string |
| http://purl.uniprot.org/citations/19095286 | http://purl.uniprot.org/core/author | "Jin Y."xsd:string |
| http://purl.uniprot.org/citations/19095286 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/19095286 | http://purl.uniprot.org/core/author | "Zhou L."xsd:string |
| http://purl.uniprot.org/citations/19095286 | http://purl.uniprot.org/core/author | "Sun L."xsd:string |
| http://purl.uniprot.org/citations/19095286 | http://purl.uniprot.org/core/author | "Wang W."xsd:string |
| http://purl.uniprot.org/citations/19095286 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19095286 | http://purl.uniprot.org/core/name | "Chemosphere"xsd:string |
| http://purl.uniprot.org/citations/19095286 | http://purl.uniprot.org/core/pages | "1238-1244"xsd:string |
| http://purl.uniprot.org/citations/19095286 | http://purl.uniprot.org/core/title | "Enantioselective induction of estrogen-responsive gene expression by permethrin enantiomers in embryo-larval zebrafish."xsd:string |
| http://purl.uniprot.org/citations/19095286 | http://purl.uniprot.org/core/volume | "74"xsd:string |
| http://purl.uniprot.org/citations/19095286 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19095286 |
| http://purl.uniprot.org/citations/19095286 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19095286 |
| http://purl.uniprot.org/uniprot/O42145#attribution-5D69242E2CEDFE44C0C2F545A23EA995 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19095286 |
| http://purl.uniprot.org/uniprot/P57717#attribution-5D69242E2CEDFE44C0C2F545A23EA995 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19095286 |
| http://purl.uniprot.org/uniprot/A0A8M3AME1#attribution-5D69242E2CEDFE44C0C2F545A23EA995 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19095286 |
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| http://purl.uniprot.org/uniprot/Q1LWN2#attribution-5D69242E2CEDFE44C0C2F545A23EA995 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19095286 |
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| http://purl.uniprot.org/uniprot/Q1MTC4#attribution-5D69242E2CEDFE44C0C2F545A23EA995 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/19095286 |