| http://purl.uniprot.org/citations/19096126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19096126 | http://www.w3.org/2000/01/rdf-schema#comment | "Hypoxia-inducible factor (HIF)-1alpha and vascular endothelial growth factor (VEGF) are important angiogenic factors in human cancers. Relative to VEGF-C, prognostic significance of VEGF-D expression and its association with HIF-1alpha expression remain elusive in esophageal squamous cell cancer (ESCC). We studied expression of HIF-1alpha and VEGF-D using immunohistochemistry in 85 resected ESCC specimens and correlated results with patients' clinicopathologic parameters and survival. Association between expression of HIF-1alpha and VEGF-D was investigated using a concordance analysis. High expression of HIF-1alpha and VEGF-D was observed in 52 (61.2%) and 56 (65.9%) patients, respectively. HIF-1alpha expression correlated well with tumor stage (P = 0.041), whereas VEGF-D expression correlated with tumor stage (P = 0.027) and N status (P = 0.019). Groups of high HIF-1alpha and VEGF-D showed worse survivals than those of low expression (P = 0.002 and 0.001, respectively). Multivariate analysis supported expression of HIF-1alpha and VEGF-D as significant survival predictors (P = 0.044 and 0.035, respectively). A concordance rate of 69.5% was observed between expression of HIF-1alpha and VEGF-D. In conclusion, protein expression of HIF-1alpha and VEGF-D are independent prognostic predictors. An association between expression of HIF-1alpha and VEGF-D suggests that these two angiogenic factors are essential in progression of ESCC."xsd:string |
| http://purl.uniprot.org/citations/19096126 | http://purl.org/dc/terms/identifier | "doi:10.1155/2008/468323"xsd:string |
| http://purl.uniprot.org/citations/19096126 | http://purl.uniprot.org/core/author | "Lee S.C."xsd:string |
| http://purl.uniprot.org/citations/19096126 | http://purl.uniprot.org/core/author | "Cheng Y.L."xsd:string |
| http://purl.uniprot.org/citations/19096126 | http://purl.uniprot.org/core/author | "Hsu W.H."xsd:string |
| http://purl.uniprot.org/citations/19096126 | http://purl.uniprot.org/core/author | "Sun G.H."xsd:string |
| http://purl.uniprot.org/citations/19096126 | http://purl.uniprot.org/core/author | "Yu C.P."xsd:string |
| http://purl.uniprot.org/citations/19096126 | http://purl.uniprot.org/core/author | "Jin J.S."xsd:string |
| http://purl.uniprot.org/citations/19096126 | http://purl.uniprot.org/core/author | "Hsu H.S."xsd:string |
| http://purl.uniprot.org/citations/19096126 | http://purl.uniprot.org/core/author | "Tzao C."xsd:string |
| http://purl.uniprot.org/citations/19096126 | http://purl.uniprot.org/core/author | "Tung H.J."xsd:string |
| http://purl.uniprot.org/citations/19096126 | http://purl.uniprot.org/core/date | "2008"xsd:gYear |
| http://purl.uniprot.org/citations/19096126 | http://purl.uniprot.org/core/name | "Dis Markers"xsd:string |
| http://purl.uniprot.org/citations/19096126 | http://purl.uniprot.org/core/pages | "141-148"xsd:string |
| http://purl.uniprot.org/citations/19096126 | http://purl.uniprot.org/core/title | "Expression of hypoxia-inducible factor (HIF)-1alpha and vascular endothelial growth factor (VEGF)-D as outcome predictors in resected esophageal squamous cell carcinoma."xsd:string |
| http://purl.uniprot.org/citations/19096126 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/19096126 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/19096126 |
| http://purl.uniprot.org/citations/19096126 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/19096126 |
| http://purl.uniprot.org/uniprot/#_D0VY79-mappedCitation-19096126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19096126 |
| http://purl.uniprot.org/uniprot/#_B2R617-mappedCitation-19096126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19096126 |
| http://purl.uniprot.org/uniprot/#_A8MYV6-mappedCitation-19096126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19096126 |
| http://purl.uniprot.org/uniprot/#_B4E2K5-mappedCitation-19096126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19096126 |
| http://purl.uniprot.org/uniprot/#_B4E2U7-mappedCitation-19096126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19096126 |
| http://purl.uniprot.org/uniprot/#_B4DL76-mappedCitation-19096126 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/19096126 |