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http://purl.uniprot.org/citations/19096254http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/19096254http://www.w3.org/2000/01/rdf-schema#comment"

Background/aims

The human leukocyte antigen (HLA) system is an integral component of immune response. Highly polymorphic HLA genes may play a pivotal role in the response of antiviral therapy. We investigated the effects of HLA gene polymorphism on the clinical outcome of chronic hepatitis B patients who received lamivudine treatment.

Methods

Depending on their clinical response to lamivudine therapy, a total of sixty one patients were divided into following groups; non-responders, viral breakthroughers, relapsers, and seroconverters. HLA-A, -B, -Cw, -DRB and HLA-DRB1 alleles typing was performed on each group through the polymerase chain reaction and the sequence-specific oligonucleotide hybridization method. The distribution patterns of HLA-A, HLA-B, HLA-Cw, HLA-DRB, and HLA-DRB1 were then analysed.

Results

When non-responders were compared to the other groups, high frequencies in HLA-Cw1, HLA-DRB14 and HLA-DRB4 (p=0.015, 0.033 and 0.004 respectively) were evident. When seroconverters were compared to viral breakthroughers, high frequencies in HLA-A2 and HLA-DRB4 (p=0.048, 0.025 respectively) were evident.

Conclusions

Our data suggests that HLA-A2, HLA-Cw1, HLA-DRB14 genes are related to the clinical outcomes of lamivudine treatment in chronic hepatitis B patients. These genes may be used in the prediction of the clinical outcome of lamivudine therapy in chronic hepatitis B patients."xsd:string
http://purl.uniprot.org/citations/19096254http://purl.uniprot.org/core/author"Lee K.H."xsd:string
http://purl.uniprot.org/citations/19096254http://purl.uniprot.org/core/author"Lee S.H."xsd:string
http://purl.uniprot.org/citations/19096254http://purl.uniprot.org/core/author"Lee Y.J."xsd:string
http://purl.uniprot.org/citations/19096254http://purl.uniprot.org/core/author"Kim J.E."xsd:string
http://purl.uniprot.org/citations/19096254http://purl.uniprot.org/core/author"Park M.Y."xsd:string
http://purl.uniprot.org/citations/19096254http://purl.uniprot.org/core/author"Choi J.H."xsd:string
http://purl.uniprot.org/citations/19096254http://purl.uniprot.org/core/author"Jung M.K."xsd:string
http://purl.uniprot.org/citations/19096254http://purl.uniprot.org/core/author"Oh J.M."xsd:string
http://purl.uniprot.org/citations/19096254http://purl.uniprot.org/core/author"Kwon K.H."xsd:string
http://purl.uniprot.org/citations/19096254http://purl.uniprot.org/core/author"Beom S.H."xsd:string
http://purl.uniprot.org/citations/19096254http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/19096254http://purl.uniprot.org/core/name"Korean J Gastroenterol"xsd:string
http://purl.uniprot.org/citations/19096254http://purl.uniprot.org/core/pages"368-375"xsd:string
http://purl.uniprot.org/citations/19096254http://purl.uniprot.org/core/title"[Clinical outcomes of lamivudine therapy and HLA alleles in chronic hepatitis B patients]."xsd:string
http://purl.uniprot.org/citations/19096254http://purl.uniprot.org/core/volume"52"xsd:string
http://purl.uniprot.org/citations/19096254http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19096254
http://purl.uniprot.org/citations/19096254http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/19096254
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