| http://purl.uniprot.org/citations/19098920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19098920 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19098920 | http://www.w3.org/2000/01/rdf-schema#comment | "The Fc receptor common gamma-chain (FcRgamma) is a widely expressed adaptor bearing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. We show here that basophils lacking FcRgamma developed normally and proliferated efficiently in response to interleukin 3 (IL-3) but were very impaired in IL-3-induced production of IL-4 and in supporting T helper type 2 differentiation. Through its transmembrane portion, FcRgamma associated constitutively with the common beta-chain of the IL-3 receptor and signaled by recruiting the kinase Syk. Retrovirus-mediated complementation demonstrated the essential function of the ITAM of FcRgamma in IL-3 signal transduction. Our results identify a previously unknown mechanism whereby FcRgamma functions to 'route' selective cytokine-triggered signals into the ITAM-mediated IL-4 production pathway."xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1686"xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni.1686"xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.uniprot.org/core/author | "Saito T."xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.uniprot.org/core/author | "Sakamoto Y."xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.uniprot.org/core/author | "Sakamoto Y."xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.uniprot.org/core/author | "Yamasaki S."xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.uniprot.org/core/author | "Yamasaki S."xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.uniprot.org/core/author | "Obata K."xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.uniprot.org/core/author | "Obata K."xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.uniprot.org/core/author | "Takai T."xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.uniprot.org/core/author | "Takai T."xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.uniprot.org/core/author | "Taki S."xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.uniprot.org/core/author | "Taki S."xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.uniprot.org/core/author | "Karasuyama H."xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.uniprot.org/core/author | "Karasuyama H."xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.uniprot.org/core/author | "Sugane K."xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.uniprot.org/core/author | "Sugane K."xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.uniprot.org/core/author | "Hida S."xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.uniprot.org/core/author | "Hida S."xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.uniprot.org/core/author | "Takamoto M."xsd:string |
| http://purl.uniprot.org/citations/19098920 | http://purl.uniprot.org/core/author | "Takamoto M."xsd:string |