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http://purl.uniprot.org/citations/19100004http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Objective

To investigate the relationship between polymorphism of Ghrelin gene and serum levels of lipoprotein in Han Chinese with or without coronary heart disease (CHD) risk factors.

Methods

PCR restriction fragment length polymorphism assay was used to detect the distribution of genotypes of Ghrelin gene in 225 Han Chinese (40 to 69 years-old) with CHD risk factors, 78 subjects without CHD risk factors served as normal controls. Serum levels of total cholesterol (TC), triglyceride (TG), high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL-C) and very low-density lipoprotein (VLDL) were measured to analyze the relationship with the polymorphism of Ghrelin gene.

Results

Ghrelin genotype frequencies of AA, AG, GG (0.975, 0.025, 0.00 in control group and 0.956, 0.040, 0.004 in the high-risk group, all P > 0.05) as well as the allele frequencies of A, G (0.987, 0.013 in control group and 0.976, 0.024 in the high-risk group, all P > 0.05) were similar between the groups. HDL-C levels of the Arg/Gln carriers were significantly lower than those of Arg/Arg carriers in control group and in the high-risk group (all P < 0.05).

Conclusion

Arg/Gln carriers were associated lower HDL-C levels in Han Chinese."xsd:string
http://purl.uniprot.org/citations/19100004http://purl.uniprot.org/core/author"Zhang J."xsd:string
http://purl.uniprot.org/citations/19100004http://purl.uniprot.org/core/author"Xie X."xsd:string
http://purl.uniprot.org/citations/19100004http://purl.uniprot.org/core/author"Wang J.H."xsd:string
http://purl.uniprot.org/citations/19100004http://purl.uniprot.org/core/author"Wang Y.H."xsd:string
http://purl.uniprot.org/citations/19100004http://purl.uniprot.org/core/author"Zhang C.H."xsd:string
http://purl.uniprot.org/citations/19100004http://purl.uniprot.org/core/author"Yuan X.H."xsd:string
http://purl.uniprot.org/citations/19100004http://purl.uniprot.org/core/author"Ni H.Y."xsd:string
http://purl.uniprot.org/citations/19100004http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/19100004http://purl.uniprot.org/core/name"Zhonghua Xin Xue Guan Bing Za Zhi"xsd:string
http://purl.uniprot.org/citations/19100004http://purl.uniprot.org/core/pages"305-308"xsd:string
http://purl.uniprot.org/citations/19100004http://purl.uniprot.org/core/title"[Relationship between Ghrelin polymorphism and serum lipoprotein levels in Han Chinese with or without coronary heart disease risk factors]."xsd:string
http://purl.uniprot.org/citations/19100004http://purl.uniprot.org/core/volume"36"xsd:string
http://purl.uniprot.org/citations/19100004http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19100004
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