| http://purl.uniprot.org/citations/19100700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19100700 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19100700 | http://www.w3.org/2000/01/rdf-schema#comment | "Differentiation of memory cells involves DNA-sequence changes in B lymphocytes but is less clearly defined in T cells. RNA rearrangement is identified here as a key event in memory T cell differentiation by analysis of a mouse mutation that altered the proportions of naive and memory T cells and crippled the process of Ptprc exon silencing needed to generate CD45RO in memory T cells. A single substitution in a memory-induced RNA-binding protein, hnRNPLL, destabilized an RNA-recognition domain that bound with micromolar affinity to RNA containing the Ptprc exon-silencing sequence. Hnrpll mutation selectively diminished T cell accumulation in peripheral lymphoid tissues but not proliferation. Exon-array analysis of Hnrpll mutant naive and memory T cells revealed an extensive program of alternative mRNA splicing in memory T cells, coordinated by hnRNPLL. A remarkable overlap with alternative splicing in neural tissues may reflect a co-opted strategy for diversifying memory T cells."xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2008.11.004"xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.immuni.2008.11.004"xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.uniprot.org/core/author | "Jia X."xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.uniprot.org/core/author | "Jia X."xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.uniprot.org/core/author | "Otting G."xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.uniprot.org/core/author | "Otting G."xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.uniprot.org/core/author | "Wu Z."xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.uniprot.org/core/author | "Yu D."xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.uniprot.org/core/author | "Yu D."xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.uniprot.org/core/author | "Su X.-C."xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.uniprot.org/core/author | "Su X.-C."xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.uniprot.org/core/author | "Goodnow C.C."xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.uniprot.org/core/author | "Goodnow C.C."xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.uniprot.org/core/author | "Whittle B."xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.uniprot.org/core/author | "Whittle B."xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.uniprot.org/core/author | "Aderem A."xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.uniprot.org/core/author | "Aderem A."xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.uniprot.org/core/author | "Hamilton A."xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.uniprot.org/core/author | "Hamilton A."xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.uniprot.org/core/author | "Marzolf B."xsd:string |
| http://purl.uniprot.org/citations/19100700 | http://purl.uniprot.org/core/author | "Marzolf B."xsd:string |