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http://purl.uniprot.org/citations/19102886http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Objective

To investigate the relationship between dyslipidemia and the polymorphism of angiotensin II type 1 receptor (AT(1)R) gene A1166C in hypertensive Kazakans of Xinjiang area.

Methods

Polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP) methods were used to detect the A1166C polymorphism of AT(1)R gene of 296 hypertensive and 198 normotensive Kazakans. Biochemical parameters were measured by autochemical emalyzer.

Results

(1) The TC and LDL-C levels are significantly higher in hypertension group than those in normotensive controls [TC: (4.91 +/-1.19) mmol/L vs. (4.43 +/- 1.20) mmol/L; LDL-C: (3.36 +/-1.01) mmol/L vs. (2.94 +/-1.30) mmol/L, P < 0.001). (2) In hypertension group, TC and LDL-C are related to A1166C polymorphism of AT(1)R gene and TC and LDL-C of AC carriers are significantly higher than AA carriers (P < 0.05).

Conclusion

The dyslipidemia is related to A1166C polymorphism of AT(1)R gene in hypertensive Kazakans."xsd:string
http://purl.uniprot.org/citations/19102886http://purl.uniprot.org/core/author"Li T."xsd:string
http://purl.uniprot.org/citations/19102886http://purl.uniprot.org/core/author"Zhou L."xsd:string
http://purl.uniprot.org/citations/19102886http://purl.uniprot.org/core/author"Wang J."xsd:string
http://purl.uniprot.org/citations/19102886http://purl.uniprot.org/core/author"Wang X.L."xsd:string
http://purl.uniprot.org/citations/19102886http://purl.uniprot.org/core/author"Zhang D.L."xsd:string
http://purl.uniprot.org/citations/19102886http://purl.uniprot.org/core/author"Zhou K.M."xsd:string
http://purl.uniprot.org/citations/19102886http://purl.uniprot.org/core/author"Li N.F."xsd:string
http://purl.uniprot.org/citations/19102886http://purl.uniprot.org/core/author"Zu F.Y."xsd:string
http://purl.uniprot.org/citations/19102886http://purl.uniprot.org/core/date"2008"xsd:gYear
http://purl.uniprot.org/citations/19102886http://purl.uniprot.org/core/name"Zhonghua Xin Xue Guan Bing Za Zhi"xsd:string
http://purl.uniprot.org/citations/19102886http://purl.uniprot.org/core/pages"893-896"xsd:string
http://purl.uniprot.org/citations/19102886http://purl.uniprot.org/core/title"[The relationship between dyslipemia and the polymorphism of angiotensin II type 1 receptor gene in hypertensive Kazakans of Xinjiang.]."xsd:string
http://purl.uniprot.org/citations/19102886http://purl.uniprot.org/core/volume"36"xsd:string
http://purl.uniprot.org/citations/19102886http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/19102886
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