| http://purl.uniprot.org/citations/19103749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19103749 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/19103749 | http://www.w3.org/2000/01/rdf-schema#comment | "Acetylation of the RelA subunit of NF-kappaB, especially at lysine-310, is critical for the transcriptional activation of NF-kappaB and the expression of inflammatory genes. In this study, we demonstrate that bromodomains of Brd4 bind to acetylated lysine-310. Brd4 enhances transcriptional activation of NF-kappaB and the expression of a subset of NF-kappaB-responsive inflammatory genes in an acetylated lysine-310-dependent manner. Bromodomains of Brd4 and acetylated lysine-310 of RelA are both required for the mutual interaction and coactivation function of Brd4. Finally, we demonstrate that Brd4 further recruits CDK9 to phosphorylate C-terminal domain of RNA polymerase II and facilitate the transcription of NF-kappaB-dependent inflammatory genes. Our results identify Brd4 as a novel coactivator of NF-kappaB through specifically binding to acetylated lysine-310 of RelA. In addition, these studies reveal a mechanism by which acetylated RelA stimulates the transcriptional activity of NF-kappaB and the NF-kappaB-dependent inflammatory response."xsd:string |
| http://purl.uniprot.org/citations/19103749 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01365-08"xsd:string |
| http://purl.uniprot.org/citations/19103749 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01365-08"xsd:string |
| http://purl.uniprot.org/citations/19103749 | http://purl.uniprot.org/core/author | "Huang B."xsd:string |
| http://purl.uniprot.org/citations/19103749 | http://purl.uniprot.org/core/author | "Huang B."xsd:string |
| http://purl.uniprot.org/citations/19103749 | http://purl.uniprot.org/core/author | "Ozato K."xsd:string |
| http://purl.uniprot.org/citations/19103749 | http://purl.uniprot.org/core/author | "Ozato K."xsd:string |
| http://purl.uniprot.org/citations/19103749 | http://purl.uniprot.org/core/author | "Zhou M.M."xsd:string |
| http://purl.uniprot.org/citations/19103749 | http://purl.uniprot.org/core/author | "Zhou M.M."xsd:string |
| http://purl.uniprot.org/citations/19103749 | http://purl.uniprot.org/core/author | "Chen L.F."xsd:string |
| http://purl.uniprot.org/citations/19103749 | http://purl.uniprot.org/core/author | "Chen L.F."xsd:string |
| http://purl.uniprot.org/citations/19103749 | http://purl.uniprot.org/core/author | "Yang X.D."xsd:string |
| http://purl.uniprot.org/citations/19103749 | http://purl.uniprot.org/core/author | "Yang X.D."xsd:string |
| http://purl.uniprot.org/citations/19103749 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19103749 | http://purl.uniprot.org/core/date | "2009"xsd:gYear |
| http://purl.uniprot.org/citations/19103749 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/19103749 | http://purl.uniprot.org/core/name | "Mol. Cell. Biol."xsd:string |
| http://purl.uniprot.org/citations/19103749 | http://purl.uniprot.org/core/pages | "1375-1387"xsd:string |
| http://purl.uniprot.org/citations/19103749 | http://purl.uniprot.org/core/pages | "1375-1387"xsd:string |
| http://purl.uniprot.org/citations/19103749 | http://purl.uniprot.org/core/title | "Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA."xsd:string |
| http://purl.uniprot.org/citations/19103749 | http://purl.uniprot.org/core/title | "Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA."xsd:string |
| http://purl.uniprot.org/citations/19103749 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/19103749 | http://purl.uniprot.org/core/volume | "29"xsd:string |